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- W2416065165 abstract "Intravenous paclitaxel has been underused in dogs due to severe and acute hypersensitivity reactions. Subcutaneous (SC) administration of paclitaxel and its safety are unknown. In this preliminary study, SC administration of paclitaxel was evaluated for hypersensitivity reactions and toxicity in 21 dogs with advanced cancer. Dogs received 1 to 5 paclitaxel doses, ranging from 85 to 170 mg/m(2), SC every 14 or 21 days. A total of 40 paclitaxel doses were administered and none of the 21 dogs developed systemic or acute local hypersensitivity reactions. Severe skin lesions at the injection site developed in 2 dogs after the 4th injection at the same location. Grade 4 neutropenia was observed in 50% of the dogs 5 days after the first treatment at 115 mg/m(2) (n = 14). Two animals developed Grade 5 diarrhea and died likely due to hemodynamic failure or sepsis. Paclitaxel can be administered SC in dogs with no hypersensitivity reaction. Administration sous-cutanée de paclitaxel chez des chiens atteints du cancer: une étude préliminaire. Le paclitaxel intraveineux a été sous-utilisé chez les chiens en raison de réactions d’hypersensibilité graves et aiguës. L’administration sous-cutanée (SC) de paclitaxel et son innocuité ne sont pas connues. Dans cette étude préliminaire, l’administration SC de paclitaxel a été évaluée pour des réactions d’hypersensibilité et de toxicité chez 21 chiens atteints d’un cancer avancé. Les chiens ont reçu de 1 à 5 doses de paclitaxel, allant de 85 à 170 mg/m2 SC tous les 14 ou 21 jours. Un total de 40 doses de paclitaxel ont été administrées et aucun des 21 chiens n’a développé de réactions d’hypersensibilité systémique ou locale aiguë. Des lésions cutanées graves au site d’injection se sont développées chez deux chiens après la quatrième injection au même endroit. Une neutropénie de grade 4 a été observée chez 50 % des chiens 5 jours après le premier traitement à 115 mg/m2 (n = 14). Deux animaux ont développé une diarrhée de grade 5 et sont morts probablement à cause d’une insuffisance hémodynamique ou d’une sepsie. Le paclitaxel peut être administré SC chez les chiens sans une réaction d’hypersensibilité.(Traduit par Isabelle Vallières)." @default.
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- W2416065165 date "2015-08-01" @default.
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- W2416065165 title "Subcutaneous administration of paclitaxel in dogs with cancer: A preliminary study." @default.
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