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- W2416099076 abstract "The effect of the polyamine biosynthesis inhibitor alpha-difluoromethylornithine (DFMO) on the in vitro radiation response of Clone A human colon adenocarcinoma cells was investigated. Analysis of intracellular polyamine levels showed that exposure of Clone A cells to 1 mM DFMO for 96 h reduced putrescine and spermidine to nondetectable levels, while spermine was decreased by approximately 50%. This DFMO treatment protocol enhanced the radiosensitivity of Clone A cells, which was reflected by a decrease in both the Do and Dq. The addition of putrescine (1 mM) for the final 48 h of DFMO exposure restored polyamine levels and returned clone A radiosensitivity to that of control cells. These results indicate that polyamine depletion by DFMO sensitizes Clone A tumor cells to ionizing radiation." @default.
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- W2416099076 date "1988-06-01" @default.
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- W2416099076 title "Effects of α-Difluoromethylornithine-Induced Polyamine Depletion on the Radiosensitivity of a Human Colon Carcinoma Cell Line" @default.
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- W2416099076 doi "https://doi.org/10.2307/3577134" @default.
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