FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2416131567> ?p ?o ?g. }

• W2416131567 endingPage "1424" @default.
• W2416131567 startingPage "1418" @default.
• W2416131567 abstract "Kim, Chang-Ju, Jeong-Seop Rhee, and Norio Akaike. Modulation of high-voltage activated Ca 2+ channels in the rat periaqueductal gray neurons by μ-type opioid agonist. J. Neurophysiol. 77: 1418–1424, 1997. The effect of μ-type opioid receptor agonist, D-Ala 2 ,N-MePhe 4 ,Gly 5 -ol-enkephalin (DAMGO), on high-voltage-activated (HVA) Ca 2+ channels in the dissociated rat periaqueductal gray (PAG) neurons was investigated by the use of nystatin-perforated patch recording mode under voltage-clamp condition. Among 118 PAG neurons tested, the HVA Ca 2+ channels of 38 neurons (32%) were inhibited by DAMGO (DAMGO-sensitive cells), and the other 80 neurons (68%) were not affected by DAMGO (DAMGO-insensitive cells). The N-, P-, L-, Q-, and R-type Ca 2+ channel components in DAMGO-insensitive cells shared 26.9, 37.1, 22.3, 7.9, and 5.8%, respectively, of the total Ca 2+ channel current. The channel components of DAMGO-sensitive cells were 45.6, 25.7, 21.7, 4.6, and 2.4%, respectively. The HVA Ca 2+ current of DAMGO-sensitive neurons was inhibited by DAMGO in a concentration-, time-, and voltage-dependent manner. Application of ω-conotoxin-GVIA occluded the inhibitory effect of DAMGO ∼70%. So, HVA Ca 2+ channels inhibited by DAMGO were mainly the N-type Ca 2+ channels. The inhibitory effect of DAMGO on HVA Ca 2+ channels was prevented almost completely by the pretreatment of pertussis toxin (PTX) for 8–10 h, suggesting that DAMGO modulation on N-type Ca 2+ channels in rat PAG neurons is mediated by PTX-sensitive G proteins. These results indicate that μ-type opioid receptor modulates N-type HVA Ca 2+ channels via PTX-sensitive G proteins in PAG neurons of rats." @default.
• W2416131567 created "2016-06-24" @default.
• W2416131567 creator A5031937425 @default.
• W2416131567 creator A5067673672 @default.
• W2416131567 creator A5087513369 @default.
• W2416131567 date "1997-03-01" @default.
• W2416131567 modified "2023-10-17" @default.
• W2416131567 title "Modulation of High-Voltage Activated Ca²⁺ Channels in the Rat Periaqueductal Gray Neurons by μ-Type Opioid Agonist" @default.
• W2416131567 cites W1527273445 @default.
• W2416131567 cites W1824515686 @default.
• W2416131567 cites W1908503105 @default.
• W2416131567 cites W1968009058 @default.
• W2416131567 cites W1980325410 @default.
• W2416131567 cites W1984800507 @default.
• W2416131567 cites W1992682983 @default.
• W2416131567 cites W2000549249 @default.
• W2416131567 cites W2002959402 @default.
• W2416131567 cites W2007622582 @default.
• W2416131567 cites W2012119611 @default.
• W2416131567 cites W2019365444 @default.
• W2416131567 cites W2022559948 @default.
• W2416131567 cites W2025267797 @default.
• W2416131567 cites W2025414544 @default.
• W2416131567 cites W2025932530 @default.
• W2416131567 cites W2028833035 @default.
• W2416131567 cites W2036320267 @default.
• W2416131567 cites W2037175122 @default.
• W2416131567 cites W2039231750 @default.
• W2416131567 cites W2039527361 @default.
• W2416131567 cites W2047458497 @default.
• W2416131567 cites W2060094414 @default.
• W2416131567 cites W2060999820 @default.
• W2416131567 cites W2061056399 @default.
• W2416131567 cites W2067049451 @default.
• W2416131567 cites W2067935544 @default.
• W2416131567 cites W2070034006 @default.
• W2416131567 cites W2084165595 @default.
• W2416131567 cites W2085683835 @default.
• W2416131567 cites W2090981990 @default.
• W2416131567 cites W2091061257 @default.
• W2416131567 cites W2095326121 @default.
• W2416131567 cites W2140257707 @default.
• W2416131567 cites W2147107991 @default.
• W2416131567 cites W2155040131 @default.
• W2416131567 cites W2169352888 @default.
• W2416131567 cites W2170912183 @default.
• W2416131567 cites W2398218032 @default.
• W2416131567 cites W2466680436 @default.
• W2416131567 doi "https://doi.org/10.1152/jn.1997.77.3.1418" @default.
• W2416131567 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9084607" @default.
• W2416131567 hasPublicationYear "1997" @default.
• W2416131567 type Work @default.
• W2416131567 sameAs 2416131567 @default.
• W2416131567 citedByCount "46" @default.
• W2416131567 countsByYear W24161315672012 @default.
• W2416131567 countsByYear W24161315672015 @default.
• W2416131567 countsByYear W24161315672016 @default.
• W2416131567 countsByYear W24161315672019 @default.
• W2416131567 countsByYear W24161315672020 @default.
• W2416131567 countsByYear W24161315672022 @default.
• W2416131567 crossrefType "journal-article" @default.
• W2416131567 hasAuthorship W2416131567A5031937425 @default.
• W2416131567 hasAuthorship W2416131567A5067673672 @default.
• W2416131567 hasAuthorship W2416131567A5087513369 @default.
• W2416131567 hasBestOaLocation W24161315671 @default.
• W2416131567 hasConcept C12554922 @default.
• W2416131567 hasConcept C126322002 @default.
• W2416131567 hasConcept C134018914 @default.
• W2416131567 hasConcept C14397066 @default.
• W2416131567 hasConcept C170493617 @default.
• W2416131567 hasConcept C185592680 @default.
• W2416131567 hasConcept C2776401185 @default.
• W2416131567 hasConcept C2777803847 @default.
• W2416131567 hasConcept C2778938600 @default.
• W2416131567 hasConcept C2779886867 @default.
• W2416131567 hasConcept C2781063702 @default.
• W2416131567 hasConcept C2781069035 @default.
• W2416131567 hasConcept C529278444 @default.
• W2416131567 hasConcept C552161191 @default.
• W2416131567 hasConcept C55493867 @default.
• W2416131567 hasConcept C71924100 @default.
• W2416131567 hasConcept C86803240 @default.
• W2416131567 hasConceptScore W2416131567C12554922 @default.
• W2416131567 hasConceptScore W2416131567C126322002 @default.
• W2416131567 hasConceptScore W2416131567C134018914 @default.
• W2416131567 hasConceptScore W2416131567C14397066 @default.
• W2416131567 hasConceptScore W2416131567C170493617 @default.
• W2416131567 hasConceptScore W2416131567C185592680 @default.
• W2416131567 hasConceptScore W2416131567C2776401185 @default.
• W2416131567 hasConceptScore W2416131567C2777803847 @default.
• W2416131567 hasConceptScore W2416131567C2778938600 @default.
• W2416131567 hasConceptScore W2416131567C2779886867 @default.
• W2416131567 hasConceptScore W2416131567C2781063702 @default.
• W2416131567 hasConceptScore W2416131567C2781069035 @default.
• W2416131567 hasConceptScore W2416131567C529278444 @default.
• W2416131567 hasConceptScore W2416131567C552161191 @default.
• W2416131567 hasConceptScore W2416131567C55493867 @default.
• W2416131567 hasConceptScore W2416131567C71924100 @default.

• next