FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2416198583> ?p ?o ?g. }

• W2416198583 endingPage "e010142" @default.
• W2416198583 startingPage "e010142" @default.
• W2416198583 abstract "Introduction There have been inconsistent findings from randomised controlled trials (RCTs) and systematic reviews on the efficacies of selective serotonin reuptake inhibitors (SSRIs) as the first-line treatment of major depressive disorder (MDD). Besides inconsistencies among randomised controlled trials (RCTs), their risks of bias and evidence grading have seldom been evaluated in meta-analysis. This study aims to compare the efficacy of SSRIs by conducting a Bayesian network meta-analysis, which will be the most comprehensive evaluation of evidence to resolve the inconsistency among previous studies. Methods and analyses SSRIs including citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline and vilazodone have been selected. Systematic database searching and screening will be conducted for the RCTs on drug treatment of patients with MDD according to pre-specified search strategies and selection criteria. PubMed, the Cochrane Library, EMBASE, ScienceDirect, the US Food and Drug Administration Website, ClinicalTrial.gov and WHO Clinical Trials will be searched. Outcome data including Hamilton Depression Rating Scale (HDRS), Montgomery-Asberg Depression Rating Scale (MADRS) and Clinical Global Impression (CGI) from eligible RCTs will be extracted. The outcomes will be analysed as ORs and mean differences under a random-effects model. A Bayesian network meta-analysis will be conducted with WinBUGS software, to compare the efficacies of SSRIs. Subgroup and sensitivity analysis will be performed to explain the study heterogeneity and evaluate the robustness of the results. Meta-regression analysis will be conducted to determine the possible factors affecting the efficacy outcomes. The Cochrane risk of bias assessment tool will be used to assess the RCT quality, and the Grading of Recommendation, Assessment, Development and Evaluation will be used to assess the strength of evidence from the meta-analysis. Ethics and dissemination No ethical approval is required because this study includes neither confidential personal patient data nor interventions with patients. Protocol registration number CRD42015024879." @default.
• W2416198583 created "2016-06-24" @default.
• W2416198583 creator A5028696869 @default.
• W2416198583 creator A5056022101 @default.
• W2416198583 creator A5091418371 @default.
• W2416198583 date "2016-06-01" @default.
• W2416198583 modified "2023-10-15" @default.
• W2416198583 title "Comparative efficacy of selective serotonin reuptake inhibitors (SSRI) in treating major depressive disorder: a protocol for network meta-analysis of randomised controlled trials" @default.
• W2416198583 cites W1247968195 @default.
• W2416198583 cites W1496777514 @default.
• W2416198583 cites W1517555081 @default.
• W2416198583 cites W1534047151 @default.
• W2416198583 cites W1971355892 @default.
• W2416198583 cites W1971895240 @default.
• W2416198583 cites W1984135336 @default.
• W2416198583 cites W2004762037 @default.
• W2416198583 cites W2015700432 @default.
• W2416198583 cites W2022039920 @default.
• W2416198583 cites W2028012695 @default.
• W2416198583 cites W2028896243 @default.
• W2416198583 cites W2031229007 @default.
• W2416198583 cites W2079198918 @default.
• W2416198583 cites W2082270426 @default.
• W2416198583 cites W2097197321 @default.
• W2416198583 cites W2098235344 @default.
• W2416198583 cites W2099328792 @default.
• W2416198583 cites W2109553753 @default.
• W2416198583 cites W2116153150 @default.
• W2416198583 cites W2132577167 @default.
• W2416198583 cites W2143973670 @default.
• W2416198583 cites W2149154629 @default.
• W2416198583 cites W2151525837 @default.
• W2416198583 cites W2153403353 @default.
• W2416198583 cites W2156098321 @default.
• W2416198583 cites W2159011576 @default.
• W2416198583 cites W2161817962 @default.
• W2416198583 cites W2162865096 @default.
• W2416198583 cites W2189057525 @default.
• W2416198583 cites W2280324292 @default.
• W2416198583 cites W2991792334 @default.
• W2416198583 cites W1606366448 @default.
• W2416198583 doi "https://doi.org/10.1136/bmjopen-2015-010142" @default.
• W2416198583 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4908880" @default.
• W2416198583 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27267106" @default.
• W2416198583 hasPublicationYear "2016" @default.
• W2416198583 type Work @default.
• W2416198583 sameAs 2416198583 @default.
• W2416198583 citedByCount "4" @default.
• W2416198583 countsByYear W24161985832016 @default.
• W2416198583 countsByYear W24161985832017 @default.
• W2416198583 countsByYear W24161985832020 @default.
• W2416198583 crossrefType "journal-article" @default.
• W2416198583 hasAuthorship W2416198583A5028696869 @default.
• W2416198583 hasAuthorship W2416198583A5056022101 @default.
• W2416198583 hasAuthorship W2416198583A5091418371 @default.
• W2416198583 hasBestOaLocation W24161985831 @default.
• W2416198583 hasConcept C118552586 @default.
• W2416198583 hasConcept C126322002 @default.
• W2416198583 hasConcept C139719470 @default.
• W2416198583 hasConcept C142724271 @default.
• W2416198583 hasConcept C162324750 @default.
• W2416198583 hasConcept C168563851 @default.
• W2416198583 hasConcept C170493617 @default.
• W2416198583 hasConcept C204787440 @default.
• W2416198583 hasConcept C2775864247 @default.
• W2416198583 hasConcept C2776134451 @default.
• W2416198583 hasConcept C2776867660 @default.
• W2416198583 hasConcept C2779177272 @default.
• W2416198583 hasConcept C2780051608 @default.
• W2416198583 hasConcept C2780092697 @default.
• W2416198583 hasConcept C2780385302 @default.
• W2416198583 hasConcept C2780733359 @default.
• W2416198583 hasConcept C2910584757 @default.
• W2416198583 hasConcept C31487548 @default.
• W2416198583 hasConcept C535046627 @default.
• W2416198583 hasConcept C558461103 @default.
• W2416198583 hasConcept C71924100 @default.
• W2416198583 hasConcept C95190672 @default.
• W2416198583 hasConcept C98274493 @default.
• W2416198583 hasConceptScore W2416198583C118552586 @default.
• W2416198583 hasConceptScore W2416198583C126322002 @default.
• W2416198583 hasConceptScore W2416198583C139719470 @default.
• W2416198583 hasConceptScore W2416198583C142724271 @default.
• W2416198583 hasConceptScore W2416198583C162324750 @default.
• W2416198583 hasConceptScore W2416198583C168563851 @default.
• W2416198583 hasConceptScore W2416198583C170493617 @default.
• W2416198583 hasConceptScore W2416198583C204787440 @default.
• W2416198583 hasConceptScore W2416198583C2775864247 @default.
• W2416198583 hasConceptScore W2416198583C2776134451 @default.
• W2416198583 hasConceptScore W2416198583C2776867660 @default.
• W2416198583 hasConceptScore W2416198583C2779177272 @default.
• W2416198583 hasConceptScore W2416198583C2780051608 @default.
• W2416198583 hasConceptScore W2416198583C2780092697 @default.
• W2416198583 hasConceptScore W2416198583C2780385302 @default.
• W2416198583 hasConceptScore W2416198583C2780733359 @default.
• W2416198583 hasConceptScore W2416198583C2910584757 @default.
• W2416198583 hasConceptScore W2416198583C31487548 @default.
• W2416198583 hasConceptScore W2416198583C535046627 @default.

• next