FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2416205153> ?p ?o ?g. }

• W2416205153 endingPage "75" @default.
• W2416205153 startingPage "68" @default.
• W2416205153 abstract "Cytokines play an important role in cell-mediated immune responses against Mycobacterium tuberculosis (Mtb) infection. Cytokine profile specifically associated with active tuberculosis (ATB) patients, subjects with latent tuberculosis infection (LTBI) and non-infected individuals remains to be determined.We enrolled a total of 92 subjects including patients with ATB (n = 25), LTBI (n = 36) and healthy controls (HC, n = 31) to investigate the cytokine production by peripheral blood mononuclear cells after Mtb purified protein derivative (PPD) stimulation which was evaluated by a beads-based multiplex assay system.The production of IL-1β, IL-2, IL-6, IL-10, IL-17, G-CSF, IFN-γ, IP-10, MIP-1α and TNF-α was abundantly induced by PPD in all three groups. The levels of IL-2, IL-10, IFN-γ, IP-10 and TNF-α were significantly higher in LTBI group than in ATB group. The combination of PPD-stimulated IL-2 and IL-10 accurately identified 84.0% of ATB and 88.9% of LTBI. We validated the use of PPD-stimulated IL-2 and IL-10 test combined with T-SPOT.TB test in a cohort of 44 subjects with TB suspicion. The sensitivity and specificity of the combined test were 83.3% and 92.3%, respectively. The PPD-stimulated IL-2/IFN-γ ratio (p < 0.001) in LTBI subjects was significantly higher than in active TB patients.Our study identified cytokine patterns characteristic of ATB and LTBI. Cytokines such as IL-2 and IL-10 may serve as biomarkers for distinguishing ATB from LTBI and healthy control and may contribute to intervention and improvement in TB diagnosis." @default.
• W2416205153 created "2016-06-24" @default.
• W2416205153 creator A5021084228 @default.
• W2416205153 creator A5036477294 @default.
• W2416205153 creator A5037005556 @default.
• W2416205153 creator A5045800846 @default.
• W2416205153 creator A5049061801 @default.
• W2416205153 creator A5059055920 @default.
• W2416205153 creator A5072012689 @default.
• W2416205153 creator A5079883289 @default.
• W2416205153 creator A5090256924 @default.
• W2416205153 date "2017-01-01" @default.
• W2416205153 modified "2023-10-16" @default.
• W2416205153 title "Multiple cytokine responses in discriminating between active tuberculosis and latent tuberculosis infection" @default.
• W2416205153 cites W1835427949 @default.
• W2416205153 cites W1901355048 @default.
• W2416205153 cites W1969623044 @default.
• W2416205153 cites W1979316802 @default.
• W2416205153 cites W1994938942 @default.
• W2416205153 cites W1998211924 @default.
• W2416205153 cites W2004811983 @default.
• W2416205153 cites W2015457648 @default.
• W2416205153 cites W2022159086 @default.
• W2416205153 cites W2023478359 @default.
• W2416205153 cites W2028901113 @default.
• W2416205153 cites W2034370582 @default.
• W2416205153 cites W2048019396 @default.
• W2416205153 cites W2058194628 @default.
• W2416205153 cites W2061021775 @default.
• W2416205153 cites W2083054031 @default.
• W2416205153 cites W2090278975 @default.
• W2416205153 cites W2098024085 @default.
• W2416205153 cites W2102738624 @default.
• W2416205153 cites W2104803911 @default.
• W2416205153 cites W2104941073 @default.
• W2416205153 cites W2105420101 @default.
• W2416205153 cites W2109244892 @default.
• W2416205153 cites W2110807603 @default.
• W2416205153 cites W2118527316 @default.
• W2416205153 cites W2121581196 @default.
• W2416205153 cites W2121711622 @default.
• W2416205153 cites W2124875533 @default.
• W2416205153 cites W2127013418 @default.
• W2416205153 cites W2133195160 @default.
• W2416205153 cites W2154501022 @default.
• W2416205153 cites W2161298902 @default.
• W2416205153 cites W2165536523 @default.
• W2416205153 cites W2166943941 @default.
• W2416205153 doi "https://doi.org/10.1016/j.tube.2016.06.001" @default.
• W2416205153 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28061954" @default.
• W2416205153 hasPublicationYear "2017" @default.
• W2416205153 type Work @default.
• W2416205153 sameAs 2416205153 @default.
• W2416205153 citedByCount "38" @default.
• W2416205153 countsByYear W24162051532017 @default.
• W2416205153 countsByYear W24162051532018 @default.
• W2416205153 countsByYear W24162051532019 @default.
• W2416205153 countsByYear W24162051532020 @default.
• W2416205153 countsByYear W24162051532021 @default.
• W2416205153 countsByYear W24162051532022 @default.
• W2416205153 countsByYear W24162051532023 @default.
• W2416205153 crossrefType "journal-article" @default.
• W2416205153 hasAuthorship W2416205153A5021084228 @default.
• W2416205153 hasAuthorship W2416205153A5036477294 @default.
• W2416205153 hasAuthorship W2416205153A5037005556 @default.
• W2416205153 hasAuthorship W2416205153A5045800846 @default.
• W2416205153 hasAuthorship W2416205153A5049061801 @default.
• W2416205153 hasAuthorship W2416205153A5059055920 @default.
• W2416205153 hasAuthorship W2416205153A5072012689 @default.
• W2416205153 hasAuthorship W2416205153A5079883289 @default.
• W2416205153 hasAuthorship W2416205153A5090256924 @default.
• W2416205153 hasConcept C137061746 @default.
• W2416205153 hasConcept C142724271 @default.
• W2416205153 hasConcept C187316574 @default.
• W2416205153 hasConcept C202751555 @default.
• W2416205153 hasConcept C203014093 @default.
• W2416205153 hasConcept C2777975735 @default.
• W2416205153 hasConcept C2778690821 @default.
• W2416205153 hasConcept C2779806340 @default.
• W2416205153 hasConcept C2781069245 @default.
• W2416205153 hasConcept C2781188995 @default.
• W2416205153 hasConcept C55493867 @default.
• W2416205153 hasConcept C60644358 @default.
• W2416205153 hasConcept C71924100 @default.
• W2416205153 hasConcept C86803240 @default.
• W2416205153 hasConcept C8891405 @default.
• W2416205153 hasConceptScore W2416205153C137061746 @default.
• W2416205153 hasConceptScore W2416205153C142724271 @default.
• W2416205153 hasConceptScore W2416205153C187316574 @default.
• W2416205153 hasConceptScore W2416205153C202751555 @default.
• W2416205153 hasConceptScore W2416205153C203014093 @default.
• W2416205153 hasConceptScore W2416205153C2777975735 @default.
• W2416205153 hasConceptScore W2416205153C2778690821 @default.
• W2416205153 hasConceptScore W2416205153C2779806340 @default.
• W2416205153 hasConceptScore W2416205153C2781069245 @default.
• W2416205153 hasConceptScore W2416205153C2781188995 @default.
• W2416205153 hasConceptScore W2416205153C55493867 @default.
• W2416205153 hasConceptScore W2416205153C60644358 @default.

• next