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- W2416231044 endingPage "2024" @default.
- W2416231044 startingPage "2014" @default.
- W2416231044 abstract "Hodgkin lymphoma (HL) has become a highly curable malignancy even in advanced stages when treated adequately. However, relapsed or refractory disease and treatment-related toxicity constitute a significant clinical challenge. Innovative approaches are thus needed to improve treatment of these mainly young patients. In HL lesions, very few malignant Hodgkin and Reed-Sternberg (HRS) cells are embedded in an immunosuppressive microenvironment of reactive cells. Novel approaches such as bispecific antibodies, antibody-drug conjugates, immune-checkpoint inhibitors or adoptive cellular therapies are currently being investigated with promising results in relapsed or refractory patients. Encouraging response rates and a favorable toxicity profile have recently been reported in early phase clinical trials with antibodies blocking the programed-death receptor 1 (PD1). This review will summarize the current clinical knowledge on mechanism, safety and efficacy of the different agents and discuss potential future strategies, which are partly already investigated within clinical trials." @default.
- W2416231044 created "2016-06-24" @default.
- W2416231044 creator A5057387418 @default.
- W2416231044 creator A5061291419 @default.
- W2416231044 creator A5064132655 @default.
- W2416231044 date "2016-05-31" @default.
- W2416231044 modified "2023-10-18" @default.
- W2416231044 title "Current and future immunotherapeutic approaches in Hodgkin lymphoma" @default.
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- W2416231044 doi "https://doi.org/10.1080/10428194.2016.1185789" @default.
- W2416231044 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27243940" @default.
- W2416231044 hasPublicationYear "2016" @default.