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• W2416257530 abstract "Randomized assignment of treatment excludes reverse causation and selection bias and, in sufficiently large studies, effectively prevents confounding. Well-implemented blinding prevents measurement bias. Studies that include these protections are called randomized, blinded clinical trials and, when conducted with sufficient numbers of patients, provide the most valid results. Although conceptually straightforward, design of clinical trials requires thoughtful trade-offs among competing approaches—all of which influence the number of patients required, enrollment time, internal and external validity, ability to evaluate interactions among treatments, and cost." @default.
• W2416257530 created "2016-06-24" @default.
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• W2416257530 date "2015-10-01" @default.
• W2416257530 modified "2023-10-01" @default.
• W2416257530 title "Clinical Research Methodology 3" @default.
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• W2416257530 doi "https://doi.org/10.1213/ane.0000000000000862" @default.
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