Matches in SemOpenAlex for { <https://semopenalex.org/work/W2416280116> ?p ?o ?g. }
- W2416280116 abstract "RotaTeqTM is a pentavalent rotavirus vaccine based on a bovine rotavirus genetic backbone in vitro reassorted with human outer capsid genes. During clinical trials of RotaTeqTM in Sub-Saharan Africa, the vaccine efficacy over a 2-year follow-up was lower against the genotypes contained in the vaccine than against the heterotypic G8P[6] and G8P[1] rotavirus strains of which the former is highly prevalent in Africa. Complete genome analyses of 43 complete rotavirus genomes collected during phase III clinical trials of RotaTeqTM in Sub-Saharan Africa, were conducted to gain insight into the high level of cross-protection afforded by RotaTeqTM against these G8 strains. Phylogenetic analysis revealed the presence of a high number of bovine rotavirus gene segments in these human G8 strains. In addition, we performed an in depth analysis on the individual amino acid level which showed that G8 rotaviruses were more similar to the RotaTeqTM vaccine than non-G8 strains. Because RotaTeqTM possesses a bovine genetic backbone, the high vaccine efficacy against G8 strains might be partially explained by the fact that all these strains contain a complete or partial bovine-like backbone. Altogether, this study supports the hypothesis that gene segments other than VP7 and VP4 play a role in vaccine-induced immunity." @default.
- W2416280116 created "2016-06-24" @default.
- W2416280116 creator A5036605970 @default.
- W2416280116 creator A5042890617 @default.
- W2416280116 creator A5043479439 @default.
- W2416280116 creator A5044984230 @default.
- W2416280116 creator A5062210570 @default.
- W2416280116 creator A5071350112 @default.
- W2416280116 creator A5090032482 @default.
- W2416280116 date "2015-10-06" @default.
- W2416280116 modified "2023-09-25" @default.
- W2416280116 title "Comparative analysis of pentavalent rotavirus vaccine strains and G8 rotaviruses identified during vaccine trial in Africa" @default.
- W2416280116 cites W1964196308 @default.
- W2416280116 cites W1966612478 @default.
- W2416280116 cites W1968659356 @default.
- W2416280116 cites W1969996683 @default.
- W2416280116 cites W1971302107 @default.
- W2416280116 cites W1974323362 @default.
- W2416280116 cites W1977281284 @default.
- W2416280116 cites W1979312283 @default.
- W2416280116 cites W1981516577 @default.
- W2416280116 cites W1990876250 @default.
- W2416280116 cites W1995283258 @default.
- W2416280116 cites W2005771314 @default.
- W2416280116 cites W2008731429 @default.
- W2416280116 cites W2012860682 @default.
- W2416280116 cites W2016767717 @default.
- W2416280116 cites W2017882908 @default.
- W2416280116 cites W2025825444 @default.
- W2416280116 cites W2031540321 @default.
- W2416280116 cites W2034899720 @default.
- W2416280116 cites W2040317656 @default.
- W2416280116 cites W2041798688 @default.
- W2416280116 cites W2046634308 @default.
- W2416280116 cites W2048170453 @default.
- W2416280116 cites W2050844412 @default.
- W2416280116 cites W2052873381 @default.
- W2416280116 cites W2054126241 @default.
- W2416280116 cites W2059317192 @default.
- W2416280116 cites W2059519302 @default.
- W2416280116 cites W2062201966 @default.
- W2416280116 cites W2066194633 @default.
- W2416280116 cites W2066359866 @default.
- W2416280116 cites W2068705108 @default.
- W2416280116 cites W2075988532 @default.
- W2416280116 cites W2083033082 @default.
- W2416280116 cites W2087242845 @default.
- W2416280116 cites W2103211789 @default.
- W2416280116 cites W2104366664 @default.
- W2416280116 cites W2104964894 @default.
- W2416280116 cites W2106428587 @default.
- W2416280116 cites W2110027469 @default.
- W2416280116 cites W2116282422 @default.
- W2416280116 cites W2118061262 @default.
- W2416280116 cites W2118496679 @default.
- W2416280116 cites W2122458999 @default.
- W2416280116 cites W2125739895 @default.
- W2416280116 cites W2131154800 @default.
- W2416280116 cites W2135985984 @default.
- W2416280116 cites W2144430726 @default.
- W2416280116 cites W2147427058 @default.
- W2416280116 cites W2152207030 @default.
- W2416280116 cites W2156728456 @default.
- W2416280116 cites W2157235080 @default.
- W2416280116 cites W2163479180 @default.
- W2416280116 cites W2163620942 @default.
- W2416280116 cites W2163975174 @default.
- W2416280116 cites W2169717660 @default.
- W2416280116 cites W4231603137 @default.
- W2416280116 doi "https://doi.org/10.1038/srep14658" @default.
- W2416280116 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4594120" @default.
- W2416280116 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26440913" @default.
- W2416280116 hasPublicationYear "2015" @default.
- W2416280116 type Work @default.
- W2416280116 sameAs 2416280116 @default.
- W2416280116 citedByCount "27" @default.
- W2416280116 countsByYear W24162801162016 @default.
- W2416280116 countsByYear W24162801162017 @default.
- W2416280116 countsByYear W24162801162018 @default.
- W2416280116 countsByYear W24162801162019 @default.
- W2416280116 countsByYear W24162801162020 @default.
- W2416280116 countsByYear W24162801162021 @default.
- W2416280116 countsByYear W24162801162022 @default.
- W2416280116 countsByYear W24162801162023 @default.
- W2416280116 crossrefType "journal-article" @default.
- W2416280116 hasAuthorship W2416280116A5036605970 @default.
- W2416280116 hasAuthorship W2416280116A5042890617 @default.
- W2416280116 hasAuthorship W2416280116A5043479439 @default.
- W2416280116 hasAuthorship W2416280116A5044984230 @default.
- W2416280116 hasAuthorship W2416280116A5062210570 @default.
- W2416280116 hasAuthorship W2416280116A5071350112 @default.
- W2416280116 hasAuthorship W2416280116A5090032482 @default.
- W2416280116 hasBestOaLocation W24162801161 @default.
- W2416280116 hasConcept C104317684 @default.
- W2416280116 hasConcept C135763542 @default.
- W2416280116 hasConcept C141231307 @default.
- W2416280116 hasConcept C159047783 @default.
- W2416280116 hasConcept C193252679 @default.
- W2416280116 hasConcept C22070199 @default.
- W2416280116 hasConcept C2522874641 @default.