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- W2416302562 abstract "L’incidence de la maladie veineuse thromboembolique (MVTE) au cours du myélome multiple (MM) dépend de son caractère de novo, persistant ou récidivant, des caractéristiques propres du patient considéré, et du type de traitement avec notamment un risque plus élevé avec le thalidomide ou le lénalidomide surtout en cas d’association à de fortes doses de dexaméthasone ou à d’autres agents de chimiothérapie. Les recommandations actuelles semblent être remises en cause par les résultats de la première étude randomisée réalisée évaluant l’aspirine, les héparines de bas poids moléculaires (HBPM) et les anti-vitamines K (AVK) dans la prophylaxie antithrombotique. Les dernières données de la littérature montrent également, qu’à l’heure actuelle, il n’est pas possible de proposer une stratégie thérapeutique prophylactique, fondée sur des preuves, de la MVTE dans le MM et que la nécessité d’une thromboprophylaxie peut être remise en question. The incidence of venous thromboembolism in multiple myeloma depends on the disease characteristics that include recent diagnosis, persistent or recurrent multiple myeloma, patient characteristics, and the type of treatment received such as thalidomide or lenalidomide especially in combination with high-dose dexamethasone, or combined chemotherapy. Currently, recommendations could be challenged by the results of the first randomized study evaluating aspirin, low molecular weight heparins and vitamin K antagonists in the antithrombotic prophylaxis. The recent data from the literature show that it is not possible to propose a therapeutic management for venous thromboembolism prophylaxis in multiple myeloma and that the use of antithrombotic prophylaxis may not be mandatory." @default.
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- W2416302562 date "2012-12-01" @default.
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- W2416302562 title "Myélome multiple de novo : faut-il proposer une prophylaxie antithrombotique ?" @default.
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- W2416302562 doi "https://doi.org/10.1016/j.revmed.2012.05.006" @default.
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