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- W2416307362 abstract "Absorption and excretion of iodixanol 320 mg I/ml were investigated in rats after intragastric administration of 2.5 g I/kg b.w. Animals were observed for up to 96 hours after treatment, and blood, urine and feces taken at several time-points throughout the experiment. Concentrations of iodixanol in serum and urine were measured by means of reversed-phase high-performance liquid chromatography. Fecal concentrations of iodixanol, based on iodine measurements, were determined by X-ray fluorescence spectrometry. Serial radiographs were obtained and histopathological examination was performed on selected tissues. The results indicate that less than 1% of the intragastric dose of iodixanol is absorbed from the intestine into the blood stream. No adverse clinical signs were observed, and there were no treatment-related histomorphological findings." @default.
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- W2416307362 date "1995-01-01" @default.
- W2416307362 modified "2023-09-25" @default.
- W2416307362 title "Absorption and Excretion of Iodixanol after Intragastric Administration to Rats" @default.
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- W2416307362 doi "https://doi.org/10.1177/0284185195036s39931" @default.
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