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• W2416361450 endingPage "45" @default.
• W2416361450 startingPage "38" @default.
• W2416361450 abstract "The Notch signaling pathway has a critical role in cell fate determination and tissue homeostasis in a variety of different lineages. In the context of normal Notch signaling, the Notch receptor of the ‘signal-receiving’ cell is activated in trans by a Notch ligand from a neighboring ‘signal-sending’ cell. Genetic studies in several model organisms have established that ubiquitination of the Notch ligand, and its regulated endocytosis, is essential for transmission of this activation signal. In mammals, this ubiquitination step is dependent on the protein Mind bomb 1 (Mib1), a large multi-domain RING-type E3 ligase, and its direct interaction with the intracellular tails of Notch ligand molecules. Here, we discuss our current understanding of Mind bomb structure and mechanism in the context of Notch signaling and beyond." @default.
• W2416361450 created "2016-06-24" @default.
• W2416361450 creator A5033196963 @default.
• W2416361450 creator A5053973336 @default.
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• W2416361450 date "2016-12-01" @default.
• W2416361450 modified "2023-10-17" @default.
• W2416361450 title "Structure and function of the Mind bomb E3 ligase in the context of Notch signal transduction" @default.
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• W2416361450 doi "https://doi.org/10.1016/j.sbi.2016.05.012" @default.
• W2416361450 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5143217" @default.
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• W2416361450 hasPublicationYear "2016" @default.
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