FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2416372007> ?p ?o ?g. }

• W2416372007 endingPage "31" @default.
• W2416372007 startingPage "23" @default.
• W2416372007 abstract "OBJECTIVE 17α-ethynylestradiol-3-sulfate (EE-3-SO 4 ) is a highly water-soluble synthetic estrogen that has an extended half-life (∼ 10 hours) over that of naturally occurring estrogen (∼ 10 minutes). In this study, EE-3-SO 4 was evaluated in a lateral fluid percussion–induced traumatic brain injury (TBI) model in rats. METHODS A total of 9 groups of Sprague-Dawley rats underwent craniectomy. Twenty-four hours later, lateral fluid percussion was applied to 6 groups of animals to induce TBI; the remaining 3 groups served as sham control groups. EE-3-SO 4 (1 mg/kg body weight in 0.4 ml/kg body weight) or saline (vehicle control) was injected intravenously 1 hour after TBI; saline was injected in all sham animals. One day after EE-3-SO 4 /saline injection, intracranial pressure (ICP), cerebral perfusion pressure (CPP), and partial brain oxygen pressure (PbtO 2 ) were measured in Groups 1–3 (2 TBI groups and 1 sham group), and brain edema, diffusion axonal injury, and cerebral glycolysis were assessed in Groups 4–6 using MRI T2 mapping, diffusion tensor imaging (DTI), and FDG-PET imaging, respectively. Four days after dosing, the open-field anxiety of animals was assessed in Groups 7–9 by measuring the duration that each animal spent in the center area of an open chamber during 4 minutes of monitoring. RESULTS EE-3-SO 4 significantly lowered ICP while raising CPP and PbtO 2 , compared with vehicle treatment in TBI-induced animals (p < 0.05). The mean size of cerebral edema of TBI animals treated with EE-3-SO 4 was 25 ± 3 mm 3 (mean ± SE), which was significantly smaller than that of vehicle-treated animals (67 ± 6 mm 3 , p < 0.001). Also, EE-3-SO 4 treatment significantly increased the fractional anisotropy of the white matter in the ipsilateral side (p = 0.003) and cerebral glycolysis (p = 0.014). The mean duration that EE-3-SO 4 -treated animals spent in the center area was 12 ± 2 seconds, which was significantly longer than that of vehicle-treated animals (4 ± 1 seconds; p = 0.008) but not different from that of sham animals (11 ± 3 seconds; p > 0.05). CONCLUSIONS These data support the clinical use of EE-3-SO 4 for early TBI treatment." @default.
• W2416372007 created "2016-06-24" @default.
• W2416372007 creator A5008732296 @default.
• W2416372007 creator A5017892395 @default.
• W2416372007 creator A5019397977 @default.
• W2416372007 creator A5044103085 @default.
• W2416372007 creator A5085171919 @default.
• W2416372007 creator A5090005178 @default.
• W2416372007 date "2017-07-01" @default.
• W2416372007 modified "2023-10-16" @default.
• W2416372007 title "Treatment of traumatic brain injury with 17α-ethinylestradiol-3-sulfate in a rat model" @default.
• W2416372007 cites W1510266002 @default.
• W2416372007 cites W1676341163 @default.
• W2416372007 cites W1813764645 @default.
• W2416372007 cites W1959763698 @default.
• W2416372007 cites W1965411311 @default.
• W2416372007 cites W1968586481 @default.
• W2416372007 cites W1981081429 @default.
• W2416372007 cites W1981904429 @default.
• W2416372007 cites W1990537235 @default.
• W2416372007 cites W1999804326 @default.
• W2416372007 cites W2000528825 @default.
• W2416372007 cites W2001479501 @default.
• W2416372007 cites W2002214289 @default.
• W2416372007 cites W2002348401 @default.
• W2416372007 cites W2003890250 @default.
• W2416372007 cites W2004662060 @default.
• W2416372007 cites W2011556767 @default.
• W2416372007 cites W2014234398 @default.
• W2416372007 cites W2018233971 @default.
• W2416372007 cites W2023162219 @default.
• W2416372007 cites W2023316858 @default.
• W2416372007 cites W2025157066 @default.
• W2416372007 cites W2025590886 @default.
• W2416372007 cites W2028655978 @default.
• W2416372007 cites W2033904068 @default.
• W2416372007 cites W2039989431 @default.
• W2416372007 cites W2040674363 @default.
• W2416372007 cites W2043056601 @default.
• W2416372007 cites W2046221517 @default.
• W2416372007 cites W2046810235 @default.
• W2416372007 cites W2060908340 @default.
• W2416372007 cites W2063458512 @default.
• W2416372007 cites W2075990267 @default.
• W2416372007 cites W2086399282 @default.
• W2416372007 cites W2102889645 @default.
• W2416372007 cites W2108458189 @default.
• W2416372007 cites W2123883568 @default.
• W2416372007 cites W2127673211 @default.
• W2416372007 cites W2134186952 @default.
• W2416372007 cites W2137368645 @default.
• W2416372007 cites W2160415887 @default.
• W2416372007 cites W2166586872 @default.
• W2416372007 cites W2170921124 @default.
• W2416372007 cites W2301028673 @default.
• W2416372007 cites W2325584933 @default.
• W2416372007 cites W2415726463 @default.
• W2416372007 cites W2491392985 @default.
• W2416372007 cites W4236682564 @default.
• W2416372007 doi "https://doi.org/10.3171/2016.7.jns161263" @default.
• W2416372007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27662529" @default.
• W2416372007 hasPublicationYear "2017" @default.
• W2416372007 type Work @default.
• W2416372007 sameAs 2416372007 @default.
• W2416372007 citedByCount "24" @default.
• W2416372007 countsByYear W24163720072017 @default.
• W2416372007 countsByYear W24163720072018 @default.
• W2416372007 countsByYear W24163720072019 @default.
• W2416372007 countsByYear W24163720072020 @default.
• W2416372007 countsByYear W24163720072021 @default.
• W2416372007 countsByYear W24163720072022 @default.
• W2416372007 crossrefType "journal-article" @default.
• W2416372007 hasAuthorship W2416372007A5008732296 @default.
• W2416372007 hasAuthorship W2416372007A5017892395 @default.
• W2416372007 hasAuthorship W2416372007A5019397977 @default.
• W2416372007 hasAuthorship W2416372007A5044103085 @default.
• W2416372007 hasAuthorship W2416372007A5085171919 @default.
• W2416372007 hasAuthorship W2416372007A5090005178 @default.
• W2416372007 hasConcept C118552586 @default.
• W2416372007 hasConcept C154281038 @default.
• W2416372007 hasConcept C157767197 @default.
• W2416372007 hasConcept C2777397205 @default.
• W2416372007 hasConcept C2780954326 @default.
• W2416372007 hasConcept C2781017439 @default.
• W2416372007 hasConcept C42219234 @default.
• W2416372007 hasConcept C71924100 @default.
• W2416372007 hasConceptScore W2416372007C118552586 @default.
• W2416372007 hasConceptScore W2416372007C154281038 @default.
• W2416372007 hasConceptScore W2416372007C157767197 @default.
• W2416372007 hasConceptScore W2416372007C2777397205 @default.
• W2416372007 hasConceptScore W2416372007C2780954326 @default.
• W2416372007 hasConceptScore W2416372007C2781017439 @default.
• W2416372007 hasConceptScore W2416372007C42219234 @default.
• W2416372007 hasConceptScore W2416372007C71924100 @default.
• W2416372007 hasIssue "1" @default.
• W2416372007 hasLocation W24163720071 @default.
• W2416372007 hasLocation W24163720072 @default.
• W2416372007 hasOpenAccess W2416372007 @default.

• next