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- W2416391710 abstract "In 5 adult healthy cows and 8 adult healthy horses disappearance of chloramphenicol (Ch) from blood plasma after i.v. injection of 20 mg/kg and 40 mg/kg (3 horses) of a solubilized preparation of free Ch was followed by determining plasma concentrations by a colorimetric method. Binding of Ch to plasma proteins in the 2 species was measured by equilibrium dialysis. The results are expressed as the rate constant (k’2) and half time (t½) for elimination, and the binding capacity (β) and dissociation constant of the protein-drug complex (K3) for protein binding. From these data the doses for different dosage intervals have been calculated, assuming an average susceptibility of micro-organisms of 5.μg/ml. It is suggested that treatment of horses with Ch by the intravenous route might not be feasible because of rapid elimination. In cattle considerable difficulties might arise. It is concluded that the currently recommended doses for i.m.. administration of Ch in the 2 species may be inadequate. It is shown that this rapid elimination of the drug is achieved in both species by rapid transformation of Ch to polar metabolites, and that in cattle the major metabolite appearing in urine is a Ch-glucuronide." @default.
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- W2416391710 date "1973-09-01" @default.
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- W2416391710 title "Pharmacokinetics, Plasma Protein Binding; and Dosage of Chloramphenicol in Cattle and Horses" @default.
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- W2416391710 doi "https://doi.org/10.1016/s0034-5288(18)33834-7" @default.
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