FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2416404105> ?p ?o ?g. }

• W2416404105 endingPage "45" @default.
• W2416404105 startingPage "1238" @default.
• W2416404105 abstract "Salmonella typhimurium, an organism that invades intestinal mucosa but does not elaborate a traditional enterotoxin, evokes ileal secretion by causing alterations in active sodium and chloride transport mechanisms. To evaluate the possibility that these changes in transport might be related to the adenylate cyclase-cyclic AMP or NA+-K+-adenosine triphosphatase (ATPase) systems, mucosal adenylate cyclase, cAMP phosphodiesterase, Na+-K+ and Mg++ ATPase activities, and cAMP concentrations were measured in rabbit ileal loops infected with two strains of S. typhimurium. Strain TML invades the mucosa and evokes fluid secretion whereas strain SL 1027 invades but does not evoke secretion. Cholera toxin-stimulated loops were also studied. When compared to control loops, TML-infected mucosa demonstrated a marked increase in adenylate cyclase activity, in cAMP concentration, and no change in phosphodiesterase or ATPase activities. SL 1027-infected mucosa demonstrated no change in either adenylate cyclase or ATPase activities. Indomethacin pretreatment of cyclase activation. In contrast, indomethacin pretreatment of cholera toxin exposed animals resulted in only a partial reduction of secretion while not altering the stimulation of adenylate cyclase. These results suggest that: (1) S. typhimurium causes ileal secretion by stimulating adenylate cyclase; (2) mucosal invasion alone (SL 1027) is not sufficient to activate adenylate cyclase, and (3) Na+-K+-ATPase does not appear to be involved in salmonella-induced secretion. The mechanism of salmonella activation of adenylate cyclase is unclear but apparently differs from that of cholera toxin in that it is inhibited by indomethacin. This might be explained by the participation of prostaglandins in the salmonella activation process." @default.
• W2416404105 created "2016-06-24" @default.
• W2416404105 creator A5012603391 @default.
• W2416404105 creator A5026945846 @default.
• W2416404105 creator A5067435086 @default.
• W2416404105 creator A5067932221 @default.
• W2416404105 creator A5090444603 @default.
• W2416404105 date "1975-12-01" @default.
• W2416404105 modified "2023-09-25" @default.
• W2416404105 title "Pathogenesis of Salmonella-mediated intestinal fluid secretion. Activation of adenylate cyclase and inhibition by indomethacin." @default.
• W2416404105 cites W127931682 @default.
• W2416404105 cites W1567233573 @default.
• W2416404105 cites W1601483930 @default.
• W2416404105 cites W1632230109 @default.
• W2416404105 cites W1775749144 @default.
• W2416404105 cites W1906094791 @default.
• W2416404105 cites W1967845952 @default.
• W2416404105 cites W1971833026 @default.
• W2416404105 cites W1994515872 @default.
• W2416404105 cites W1998086214 @default.
• W2416404105 cites W2023601764 @default.
• W2416404105 cites W2027122236 @default.
• W2416404105 cites W2042791370 @default.
• W2416404105 cites W2044880978 @default.
• W2416404105 cites W2058115726 @default.
• W2416404105 cites W2061029816 @default.
• W2416404105 cites W2061931317 @default.
• W2416404105 cites W2076542215 @default.
• W2416404105 cites W2093184449 @default.
• W2416404105 cites W2138243399 @default.
• W2416404105 cites W2141804782 @default.
• W2416404105 cites W2148309891 @default.
• W2416404105 cites W2153435210 @default.
• W2416404105 cites W2167597117 @default.
• W2416404105 cites W2167931286 @default.
• W2416404105 cites W2397038074 @default.
• W2416404105 cites W2399570585 @default.
• W2416404105 cites W2414998108 @default.
• W2416404105 cites W2431848956 @default.
• W2416404105 cites W2464023223 @default.
• W2416404105 cites W2798643531 @default.
• W2416404105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/172399" @default.
• W2416404105 hasPublicationYear "1975" @default.
• W2416404105 type Work @default.
• W2416404105 sameAs 2416404105 @default.
• W2416404105 citedByCount "29" @default.
• W2416404105 countsByYear W24164041052012 @default.
• W2416404105 countsByYear W24164041052020 @default.
• W2416404105 crossrefType "journal-article" @default.
• W2416404105 hasAuthorship W2416404105A5012603391 @default.
• W2416404105 hasAuthorship W2416404105A5026945846 @default.
• W2416404105 hasAuthorship W2416404105A5067435086 @default.
• W2416404105 hasAuthorship W2416404105A5067932221 @default.
• W2416404105 hasAuthorship W2416404105A5090444603 @default.
• W2416404105 hasConcept C126322002 @default.
• W2416404105 hasConcept C134018914 @default.
• W2416404105 hasConcept C180526460 @default.
• W2416404105 hasConcept C181199279 @default.
• W2416404105 hasConcept C185592680 @default.
• W2416404105 hasConcept C23265538 @default.
• W2416404105 hasConcept C2777006276 @default.
• W2416404105 hasConcept C2780069284 @default.
• W2416404105 hasConcept C2781065037 @default.
• W2416404105 hasConcept C49039625 @default.
• W2416404105 hasConcept C523546767 @default.
• W2416404105 hasConcept C54355233 @default.
• W2416404105 hasConcept C55493867 @default.
• W2416404105 hasConcept C62826618 @default.
• W2416404105 hasConcept C71924100 @default.
• W2416404105 hasConcept C86803240 @default.
• W2416404105 hasConcept C89423630 @default.
• W2416404105 hasConceptScore W2416404105C126322002 @default.
• W2416404105 hasConceptScore W2416404105C134018914 @default.
• W2416404105 hasConceptScore W2416404105C180526460 @default.
• W2416404105 hasConceptScore W2416404105C181199279 @default.
• W2416404105 hasConceptScore W2416404105C185592680 @default.
• W2416404105 hasConceptScore W2416404105C23265538 @default.
• W2416404105 hasConceptScore W2416404105C2777006276 @default.
• W2416404105 hasConceptScore W2416404105C2780069284 @default.
• W2416404105 hasConceptScore W2416404105C2781065037 @default.
• W2416404105 hasConceptScore W2416404105C49039625 @default.
• W2416404105 hasConceptScore W2416404105C523546767 @default.
• W2416404105 hasConceptScore W2416404105C54355233 @default.
• W2416404105 hasConceptScore W2416404105C55493867 @default.
• W2416404105 hasConceptScore W2416404105C62826618 @default.
• W2416404105 hasConceptScore W2416404105C71924100 @default.
• W2416404105 hasConceptScore W2416404105C86803240 @default.
• W2416404105 hasConceptScore W2416404105C89423630 @default.
• W2416404105 hasIssue "6" @default.
• W2416404105 hasLocation W24164041051 @default.
• W2416404105 hasOpenAccess W2416404105 @default.
• W2416404105 hasPrimaryLocation W24164041051 @default.
• W2416404105 hasRelatedWork W1997926865 @default.
• W2416404105 hasRelatedWork W2000995372 @default.
• W2416404105 hasRelatedWork W2013837352 @default.
• W2416404105 hasRelatedWork W2046164801 @default.
• W2416404105 hasRelatedWork W2049381782 @default.
• W2416404105 hasRelatedWork W2093836534 @default.

• next