Matches in SemOpenAlex for { <https://semopenalex.org/work/W2416420948> ?p ?o ?g. }
Showing items 1 to 59 of
59
with 100 items per page.
- W2416420948 endingPage "809" @default.
- W2416420948 startingPage "802" @default.
- W2416420948 abstract "The metabolism of salicylazosulfapyridine in steady state was studied in 26 healthy volunteers, in 19 colitis patients (17 of whom had ulcerative colitis and 2 Crohn's disease), and in 10 subjects in whom the colon had been removed (ileostomized subjects). This study provides evidence that the site of reductive cleavage of the azo linkage of salicylazosulfapyridine in man is the colon. Subjects with an intact colon excreted 60.5% ± 4.3% of the dose in the urine as sulfapyridine metabolites (which are formed after azo link cleavage), while ileostomized sub;ects excreted 7.1% ± 6.8% of the dose of sulfapyridine metabolites. The metabolic pattern of sulfapyridine in healthy volunteers was in the main similar to that in colitis patients. The serum concentrations of the various metabolites were measured in colitis patients and in ileostomized subjects. The levels of salicylazosulfapyridine on a dose of 2 gm daily were similar in the two groups with a median of about 5 µg per milliliter. The serum concentration of total sulfapyridine ranged from 17 to 40 µg per milliliter in colitis patients and from 0 to 8 µg per milliliter in ileostomized subjects. Phenobarbital sodium, 50 mg nightly, was taken for 5 to 7 nights. In subjects with an intact colon phenobarbital depressed the urinary excretion of salicylazosulfapyridine by 18%, either by induction of a hepatic azo reductase or by enhancement of the biliary excretion of the drug. The proportions in urine of O-glucuronidized sulfapyridine were increased by 10%, at the cost of acetylation of sulfapyridine. Phenobarbital had no detectable effects on the metabolic pattern of salicylazosulfapyridine in ileostomized subjects." @default.
- W2416420948 created "2016-06-24" @default.
- W2416420948 creator A5023706912 @default.
- W2416420948 creator A5049350495 @default.
- W2416420948 creator A5091337554 @default.
- W2416420948 date "1973-09-01" @default.
- W2416420948 modified "2023-10-11" @default.
- W2416420948 title "Metabolism of salicylazosulfapyridine in healthy subjects and in patients with ulcerative colitis; Effects of colectomy and of phenobarbital" @default.
- W2416420948 doi "https://doi.org/10.1002/cpt1973145802" @default.
- W2416420948 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4147120" @default.
- W2416420948 hasPublicationYear "1973" @default.
- W2416420948 type Work @default.
- W2416420948 sameAs 2416420948 @default.
- W2416420948 citedByCount "63" @default.
- W2416420948 countsByYear W24164209482020 @default.
- W2416420948 crossrefType "journal-article" @default.
- W2416420948 hasAuthorship W2416420948A5023706912 @default.
- W2416420948 hasAuthorship W2416420948A5049350495 @default.
- W2416420948 hasAuthorship W2416420948A5091337554 @default.
- W2416420948 hasConcept C126322002 @default.
- W2416420948 hasConcept C2775862500 @default.
- W2416420948 hasConcept C2776667177 @default.
- W2416420948 hasConcept C2778793413 @default.
- W2416420948 hasConcept C2779134260 @default.
- W2416420948 hasConcept C2780479503 @default.
- W2416420948 hasConcept C62231903 @default.
- W2416420948 hasConcept C71924100 @default.
- W2416420948 hasConcept C90924648 @default.
- W2416420948 hasConceptScore W2416420948C126322002 @default.
- W2416420948 hasConceptScore W2416420948C2775862500 @default.
- W2416420948 hasConceptScore W2416420948C2776667177 @default.
- W2416420948 hasConceptScore W2416420948C2778793413 @default.
- W2416420948 hasConceptScore W2416420948C2779134260 @default.
- W2416420948 hasConceptScore W2416420948C2780479503 @default.
- W2416420948 hasConceptScore W2416420948C62231903 @default.
- W2416420948 hasConceptScore W2416420948C71924100 @default.
- W2416420948 hasConceptScore W2416420948C90924648 @default.
- W2416420948 hasIssue "5" @default.
- W2416420948 hasLocation W24164209481 @default.
- W2416420948 hasLocation W24164209482 @default.
- W2416420948 hasOpenAccess W2416420948 @default.
- W2416420948 hasPrimaryLocation W24164209481 @default.
- W2416420948 hasRelatedWork W2018837341 @default.
- W2416420948 hasRelatedWork W2056666990 @default.
- W2416420948 hasRelatedWork W2062132000 @default.
- W2416420948 hasRelatedWork W2070295932 @default.
- W2416420948 hasRelatedWork W2116840281 @default.
- W2416420948 hasRelatedWork W2143707273 @default.
- W2416420948 hasRelatedWork W2412711560 @default.
- W2416420948 hasRelatedWork W2414966063 @default.
- W2416420948 hasRelatedWork W82006834 @default.
- W2416420948 hasRelatedWork W2337243043 @default.
- W2416420948 hasVolume "14" @default.
- W2416420948 isParatext "false" @default.
- W2416420948 isRetracted "false" @default.
- W2416420948 magId "2416420948" @default.
- W2416420948 workType "article" @default.