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• W2416531620 endingPage "69" @default.
• W2416531620 startingPage "51" @default.
• W2416531620 abstract "The concept of the immunological surveillance against neoplastic cells was initially proposed by Erlich in 1909 and later elaborated by Burnet. This hypothesis states that the normal function of the immune system, in particular the cell-mediated immunity, is to recognize and destroy the transformed and proliferating tumor cells. The role of cell-mediated immunity during the first steps of tumorigenesis remains controversial. However, there is certain evidence about its importance in the progression and dissemination of cancer. The frequent immunosuppressed condition of cancer patients at tumor relapse or recurrence of secondary tumors is a clinical sign supporting this hypothesis, and many studies have demonstrated a defective immune response in patients diagnosed with advanced cancer. Several mechanisms of escape from the immune surveillance have been described, including the immunoselection of tumor antigen-negative variants, the downregulation of MHC class I expression, suppressive T cells, and the elaboration of immunosuppressive cytokines and other factors. Because of the technical difficulty of isolating the very small amounts from culture supernatants or body fluids, only a few of these substances have been characterized and studied with respect to their biological activity: transforming growth factor-beta (TGF-beta), the protein p15E, interleukin 10 (IL-10), prostaglandin E2 (PGE2), mucins, suppressive E-receptor (SER), immunosuppressive acidic protein (IAP), and adhesion molecules. The possibility of monitoring cancer patients by testing biochemical factors related to cancer growth led to a proposal to measure a number of these factors as tumor markers. Some of them, e.g. mucins, enjoy the consensus of the oncologic community, as for some indications they can help the clinician in the management of cancer patients. Except for the class of mucins, the other above-mentioned immunosuppressive factors have not found any clinical application in the laboratory routine because the information deriving from their measurement, although of speculative and scientific interest, has limited clinical value at present. Nevertheless, even if they have no impact on patient management, these substances do have a potential role to play in the study of cancer patients, and should be taken into account when developing new therapeutic strategies." @default.
• W2416531620 created "2016-06-24" @default.
• W2416531620 creator A5018594347 @default.
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• W2416531620 creator A5024617036 @default.
• W2416531620 creator A5054372316 @default.
• W2416531620 creator A5088022548 @default.
• W2416531620 date "1998-04-01" @default.
• W2416531620 modified "2023-10-16" @default.
• W2416531620 title "Immunosuppressive Factors: Role in Cancer Development and Progression" @default.
• W2416531620 cites W1123722611 @default.
• W2416531620 cites W143417350 @default.
• W2416531620 cites W1480346895 @default.
• W2416531620 cites W1482979909 @default.
• W2416531620 cites W1484678225 @default.
• W2416531620 cites W1493121209 @default.
• W2416531620 cites W1505475899 @default.
• W2416531620 cites W1520096473 @default.
• W2416531620 cites W1528827595 @default.
• W2416531620 cites W1537666383 @default.
• W2416531620 cites W1539607590 @default.
• W2416531620 cites W1541589221 @default.
• W2416531620 cites W1556295451 @default.
• W2416531620 cites W1557872749 @default.
• W2416531620 cites W1559731804 @default.
• W2416531620 cites W1562422876 @default.
• W2416531620 cites W1563182712 @default.
• W2416531620 cites W1576287037 @default.
• W2416531620 cites W1577847770 @default.
• W2416531620 cites W1578438134 @default.
• W2416531620 cites W1581989895 @default.
• W2416531620 cites W1589348005 @default.
• W2416531620 cites W1600679422 @default.
• W2416531620 cites W1602434848 @default.
• W2416531620 cites W1607379937 @default.
• W2416531620 cites W1627780635 @default.
• W2416531620 cites W1631437819 @default.
• W2416531620 cites W1632498578 @default.
• W2416531620 cites W1639400191 @default.
• W2416531620 cites W1669313544 @default.
• W2416531620 cites W1818230223 @default.
• W2416531620 cites W1833453188 @default.
• W2416531620 cites W1872085371 @default.
• W2416531620 cites W1915251617 @default.
• W2416531620 cites W1915795479 @default.
• W2416531620 cites W1932886090 @default.
• W2416531620 cites W1938194109 @default.
• W2416531620 cites W1942879517 @default.
• W2416531620 cites W1964006242 @default.
• W2416531620 cites W1965550919 @default.
• W2416531620 cites W1968323925 @default.
• W2416531620 cites W1968694221 @default.
• W2416531620 cites W1969124499 @default.
• W2416531620 cites W1969330135 @default.
• W2416531620 cites W1969683905 @default.
• W2416531620 cites W1969849186 @default.
• W2416531620 cites W1970154401 @default.
• W2416531620 cites W1971661892 @default.
• W2416531620 cites W1971951822 @default.
• W2416531620 cites W1972643373 @default.
• W2416531620 cites W1972940937 @default.
• W2416531620 cites W1973297864 @default.
• W2416531620 cites W1974571648 @default.
• W2416531620 cites W1974728282 @default.
• W2416531620 cites W1976661229 @default.
• W2416531620 cites W1976757484 @default.
• W2416531620 cites W1981079820 @default.
• W2416531620 cites W1982621786 @default.
• W2416531620 cites W1983356886 @default.
• W2416531620 cites W1984890362 @default.
• W2416531620 cites W1985448313 @default.
• W2416531620 cites W1985938393 @default.
• W2416531620 cites W1990689075 @default.
• W2416531620 cites W1992944693 @default.
• W2416531620 cites W1993639622 @default.
• W2416531620 cites W1994375909 @default.
• W2416531620 cites W1996701413 @default.
• W2416531620 cites W2000933552 @default.
• W2416531620 cites W2006243641 @default.
• W2416531620 cites W2006492631 @default.
• W2416531620 cites W2007020023 @default.
• W2416531620 cites W2008950908 @default.
• W2416531620 cites W2010138813 @default.
• W2416531620 cites W2010220709 @default.
• W2416531620 cites W2012082077 @default.
• W2416531620 cites W2014487380 @default.
• W2416531620 cites W2014577466 @default.
• W2416531620 cites W2015784235 @default.
• W2416531620 cites W2016184208 @default.
• W2416531620 cites W2017849135 @default.
• W2416531620 cites W2018972324 @default.
• W2416531620 cites W2021107622 @default.
• W2416531620 cites W2022471636 @default.
• W2416531620 cites W2023526675 @default.
• W2416531620 cites W2023761151 @default.
• W2416531620 cites W2024588069 @default.
• W2416531620 cites W2024982360 @default.
• W2416531620 cites W2026812426 @default.

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