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- W2416543853 abstract "The role of various polymorphisms located in the IL-18 promoter has not yet been defined with regards to patient susceptibility to SLE, and occurrence of clinical manifestations of the disease remains inconsistent.Using PCR-RFLP and DNA sequencing analysis we studied the frequency of -137 G/C (rs187238), -607 C/A (rs1946518) and -1297C/T (rs360719) polymorphisms in IL-18 promoter in patients with SLE from a sample of the Polish population.We observed that patients with SLE bearing the IL-18 -1297CC genotype exhibited a 2.536-fold increased risk of SLE incidence (95% CI=1.333-4.826, p=0.0035). We also found a significantly higher frequency of the IL-18 -1297C allele in patients than in controls, with odds ratio (OR) for the IL-18 -1297C allele in patients with SLE being 1.558 (95% CI=1.189-2.041, p=0.0013). Moreover, there was an association between the IL-18 -1297CC genotype and renal manifestations of SLE, OR=3.792 (1.446-9.947, p=0.0051). However, we did not find any contribution of the IL-18 -607 C/A and -137 G/C polymorphisms to SLE incidence or occurrence of the studied SLE manifestations.Our findings confirmed that the IL-18 -1297C gene variant may contribute to the risk of SLE incidence. Moreover, IL-18 -1297CC might be associated with renal manifestations of SLE." @default.
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- W2416543853 date "2011-04-08" @default.
- W2416543853 modified "2023-10-18" @default.
- W2416543853 title "Interleukin-18 promoter polymorphisms in patients with systemic lupus erythematosus." @default.
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