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- W2416575024 abstract "Objective To investigate the association of genetic polymorphism of dendritic cellspecific ICAM-grabbing nonintegrin(DC-SIGNR)and hepatitis C infection.Methods Patients with hepatitis C(n=268)were genotyped and analysed for the repeat sequences polymorphism of DC-SIGNR using PCR and DNA sequencing.HCV virus load and HCV RNA genotypes were analyzed.Inter-group comparison was analyzed using LSD method.Results No significant correlation was found between DC-SIGNR genotypes/alleles and HCV RNA genotypes in patients.HCV-infected patients with 7-repeat(medium)alleles had lower HCV RNA levels compared to patients with 9-repeat(onger)alleles(P=0.036).HCV-infected patients with 7/7 genotype had lower HCV RNA levels compared to patients with 9/7 genotype(P=0.025).These findings suggest that optimal attachment of hepatitis C virions to DC-SIGNR may be associated with longer alleles.Conclusion The fact that DC-SIGNR polymorphism might affect HCV loads suppons the concept that DC-SIGNR contributes to HCV replication efficacy.There is no significant correlation between the genetic polymorphism of DC-SIGNR and HCV-RNA genotypes.Key words: Hepatitis C:Hepatitis C virus; Genotype; Dendritic cell-specific ICAM-3 grabbing nonintegrin related" @default.
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- W2416575024 date "2009-09-01" @default.
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- W2416575024 title "[The association of genetic polymorphism of dendritic cell-specific ICAM-grabbing nonintegrin and hepatitis C infection]." @default.
- W2416575024 doi "https://doi.org/10.3760/cma.j.issn.1007-3418.2009.09.002" @default.
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