Matches in SemOpenAlex for { <https://semopenalex.org/work/W2416583531> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2416583531 endingPage "F1196" @default.
- W2416583531 startingPage "F1191" @default.
- W2416583531 abstract "Epidermal growth factor (EGF) is a potent polypeptide mitogen with various receptor-mediated growth effects on cells from the skin, breast, and gastrointestinal tract. Recent studies indicate that EGF is produced in the kidney and is excreted in the urine, but the biological significance of renal EGF is uncertain. We demonstrate in vitro mitogenicity of EGF for LLC-PK1 cells, a tubular epithelial cell line derived from pig kidney cortex. Furthermore, when subconfluent monolayers of LLC-PK1 cells are exposed to EGF for 24 h, sodium-dependent phosphate transport is stimulated (209-410% of control). These cells possess EGF-specific high-affinity binding sites at their surface (Kd 300-700 pM) but cannot synthesize the growth factor. EGF binding sites are not a peculiarity of the LLC-PK1 cell line, since similar sites are present on MDCK cells (derived from dog kidney distal tubule or collecting duct), primary cultures of mouse proximal tubular cells, and freshly prepared membrane fractions from mouse kidney. Cortical basolateral membranes are highly enriched in EGF binding sites, whereas EGF binding by brush-border membrane fractions is minimal and is compatible with contamination." @default.
- W2416583531 created "2016-06-24" @default.
- W2416583531 creator A5000362238 @default.
- W2416583531 creator A5030047162 @default.
- W2416583531 creator A5041648961 @default.
- W2416583531 creator A5089015227 @default.
- W2416583531 date "1988-12-01" @default.
- W2416583531 modified "2023-09-27" @default.
- W2416583531 title "Renal tubular cells are potential targets for epidermal growth factor" @default.
- W2416583531 doi "https://doi.org/10.1152/ajprenal.1988.255.6.f1191" @default.
- W2416583531 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3264462" @default.
- W2416583531 hasPublicationYear "1988" @default.
- W2416583531 type Work @default.
- W2416583531 sameAs 2416583531 @default.
- W2416583531 citedByCount "25" @default.
- W2416583531 countsByYear W24165835312013 @default.
- W2416583531 countsByYear W24165835312019 @default.
- W2416583531 crossrefType "journal-article" @default.
- W2416583531 hasAuthorship W2416583531A5000362238 @default.
- W2416583531 hasAuthorship W2416583531A5030047162 @default.
- W2416583531 hasAuthorship W2416583531A5041648961 @default.
- W2416583531 hasAuthorship W2416583531A5089015227 @default.
- W2416583531 hasConcept C126322002 @default.
- W2416583531 hasConcept C130316041 @default.
- W2416583531 hasConcept C134018914 @default.
- W2416583531 hasConcept C153911025 @default.
- W2416583531 hasConcept C170493617 @default.
- W2416583531 hasConcept C185592680 @default.
- W2416583531 hasConcept C2775960820 @default.
- W2416583531 hasConcept C2776362946 @default.
- W2416583531 hasConcept C2778577996 @default.
- W2416583531 hasConcept C2780091579 @default.
- W2416583531 hasConcept C41625074 @default.
- W2416583531 hasConcept C529295009 @default.
- W2416583531 hasConcept C5426402 @default.
- W2416583531 hasConcept C54355233 @default.
- W2416583531 hasConcept C55493867 @default.
- W2416583531 hasConcept C71924100 @default.
- W2416583531 hasConcept C81885089 @default.
- W2416583531 hasConcept C86803240 @default.
- W2416583531 hasConcept C95444343 @default.
- W2416583531 hasConceptScore W2416583531C126322002 @default.
- W2416583531 hasConceptScore W2416583531C130316041 @default.
- W2416583531 hasConceptScore W2416583531C134018914 @default.
- W2416583531 hasConceptScore W2416583531C153911025 @default.
- W2416583531 hasConceptScore W2416583531C170493617 @default.
- W2416583531 hasConceptScore W2416583531C185592680 @default.
- W2416583531 hasConceptScore W2416583531C2775960820 @default.
- W2416583531 hasConceptScore W2416583531C2776362946 @default.
- W2416583531 hasConceptScore W2416583531C2778577996 @default.
- W2416583531 hasConceptScore W2416583531C2780091579 @default.
- W2416583531 hasConceptScore W2416583531C41625074 @default.
- W2416583531 hasConceptScore W2416583531C529295009 @default.
- W2416583531 hasConceptScore W2416583531C5426402 @default.
- W2416583531 hasConceptScore W2416583531C54355233 @default.
- W2416583531 hasConceptScore W2416583531C55493867 @default.
- W2416583531 hasConceptScore W2416583531C71924100 @default.
- W2416583531 hasConceptScore W2416583531C81885089 @default.
- W2416583531 hasConceptScore W2416583531C86803240 @default.
- W2416583531 hasConceptScore W2416583531C95444343 @default.
- W2416583531 hasIssue "6" @default.
- W2416583531 hasLocation W24165835311 @default.
- W2416583531 hasLocation W24165835312 @default.
- W2416583531 hasOpenAccess W2416583531 @default.
- W2416583531 hasPrimaryLocation W24165835311 @default.
- W2416583531 hasRelatedWork W1999660566 @default.
- W2416583531 hasRelatedWork W2018368842 @default.
- W2416583531 hasRelatedWork W2042033030 @default.
- W2416583531 hasRelatedWork W2098742882 @default.
- W2416583531 hasRelatedWork W2103370898 @default.
- W2416583531 hasRelatedWork W2126532023 @default.
- W2416583531 hasRelatedWork W2133525451 @default.
- W2416583531 hasRelatedWork W2144562624 @default.
- W2416583531 hasRelatedWork W2171223757 @default.
- W2416583531 hasRelatedWork W1995193459 @default.
- W2416583531 hasVolume "255" @default.
- W2416583531 isParatext "false" @default.
- W2416583531 isRetracted "false" @default.
- W2416583531 magId "2416583531" @default.
- W2416583531 workType "article" @default.