FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2416615002> ?p ?o ?g. }

• W2416615002 endingPage "8" @default.
• W2416615002 startingPage "51" @default.
• W2416615002 abstract "We have studied delayed-type hypersensitivity (DTH) responses to picryl chloride (PCl) in the lungs of mice. Intranasal challenge with 0.6% picryl sulphonic acid (PSA), a water soluble form of PCl, of BALB/c mice, sensitized with PCl epicutaneously 1 week earlier, induced an accumulation of mononuclear inflammatory cells around bronchioli and blood vessels. Maximal inflammatory responses were seen 48 hr after challenge. These responses were antigen-specific, and also T-cell dependent, since athymic nude mice failed to show this reaction. A role for mast cells in the responses was studied using two strains of mast cell-deficient mice. In one of these (W/Wv) lung DTH responses to PCl were reduced severely. In the other strain (S1/S1d) the responses around vessels were decreased slightly, whereas the responses in the interstitial tissue and around bronchioli were similar to those in +/+ littermate controls. Involvement of serotonin was investigated using two serotonin receptor antagonists, i.e. methysergide and ketanserin. Treatment of mice with either of the antagonists prevented occurrence of the DTH-like reaction in the lung after intranasal antigen challenge. In the lungs of sensitized mice, significantly increased permeability was established 2 hr after antigen challenge. It was concluded that release of serotonin in the lung may provide an environment that comprises local vascular permeability and that facilitates the local recruitment and possibly the activation of DTH effector T cells, leading to subsequent attraction of mononuclear leucocytes into the lung. Immunological regulation of the DTH-like reactions in the lung was similar to that of contact sensitivity in the skin, since intravenous injection of an antigen-specific T-cell suppressor inducer factor prior to sensitization or pretreatment with a high dose of picryl sulphonic acid intravenously both resulted in reduction of the DTH-like lung histological response to picryl sulphonic acid. From these findings it was concluded that DTH-like lung responses are similar to DTH responses in the skin." @default.
• W2416615002 created "2016-06-24" @default.
• W2416615002 creator A5023267835 @default.
• W2416615002 creator A5034364029 @default.
• W2416615002 creator A5052511743 @default.
• W2416615002 creator A5067737437 @default.
• W2416615002 creator A5077892254 @default.
• W2416615002 creator A5081852175 @default.
• W2416615002 date "1989-09-01" @default.
• W2416615002 modified "2023-09-23" @default.
• W2416615002 title "Regulation of delayed-type hypersensitivity-like responses in the mouse lung, determined with histological procedures: serotonin, T-cell suppressor-inducer factor and high antigen dose tolerance regulate the magnitude of T-cell dependent inflammatory reactions." @default.
• W2416615002 cites W1484647582 @default.
• W2416615002 cites W1490765311 @default.
• W2416615002 cites W1498297691 @default.
• W2416615002 cites W1505716994 @default.
• W2416615002 cites W1542788212 @default.
• W2416615002 cites W1555064565 @default.
• W2416615002 cites W1906219128 @default.
• W2416615002 cites W1965064476 @default.
• W2416615002 cites W1968775322 @default.
• W2416615002 cites W1973920422 @default.
• W2416615002 cites W1974207455 @default.
• W2416615002 cites W1988733687 @default.
• W2416615002 cites W2012757704 @default.
• W2416615002 cites W2036940328 @default.
• W2416615002 cites W2051163772 @default.
• W2416615002 cites W2074448969 @default.
• W2416615002 cites W2082391444 @default.
• W2416615002 cites W2121435153 @default.
• W2416615002 cites W2132505722 @default.
• W2416615002 cites W1489909005 @default.
• W2416615002 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1385504" @default.
• W2416615002 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2807371" @default.
• W2416615002 hasPublicationYear "1989" @default.
• W2416615002 type Work @default.
• W2416615002 sameAs 2416615002 @default.
• W2416615002 citedByCount "17" @default.
• W2416615002 countsByYear W24166150022012 @default.
• W2416615002 crossrefType "journal-article" @default.
• W2416615002 hasAuthorship W2416615002A5023267835 @default.
• W2416615002 hasAuthorship W2416615002A5034364029 @default.
• W2416615002 hasAuthorship W2416615002A5052511743 @default.
• W2416615002 hasAuthorship W2416615002A5067737437 @default.
• W2416615002 hasAuthorship W2416615002A5077892254 @default.
• W2416615002 hasAuthorship W2416615002A5081852175 @default.
• W2416615002 hasConcept C113045295 @default.
• W2416615002 hasConcept C126322002 @default.
• W2416615002 hasConcept C134018914 @default.
• W2416615002 hasConcept C137061746 @default.
• W2416615002 hasConcept C147483822 @default.
• W2416615002 hasConcept C170493617 @default.
• W2416615002 hasConcept C185592680 @default.
• W2416615002 hasConcept C202751555 @default.
• W2416615002 hasConcept C203014093 @default.
• W2416615002 hasConcept C2775864247 @default.
• W2416615002 hasConcept C2776914184 @default.
• W2416615002 hasConcept C2777714996 @default.
• W2416615002 hasConcept C2778786243 @default.
• W2416615002 hasConcept C2779726688 @default.
• W2416615002 hasConcept C2781005078 @default.
• W2416615002 hasConcept C55493867 @default.
• W2416615002 hasConcept C71924100 @default.
• W2416615002 hasConceptScore W2416615002C113045295 @default.
• W2416615002 hasConceptScore W2416615002C126322002 @default.
• W2416615002 hasConceptScore W2416615002C134018914 @default.
• W2416615002 hasConceptScore W2416615002C137061746 @default.
• W2416615002 hasConceptScore W2416615002C147483822 @default.
• W2416615002 hasConceptScore W2416615002C170493617 @default.
• W2416615002 hasConceptScore W2416615002C185592680 @default.
• W2416615002 hasConceptScore W2416615002C202751555 @default.
• W2416615002 hasConceptScore W2416615002C203014093 @default.
• W2416615002 hasConceptScore W2416615002C2775864247 @default.
• W2416615002 hasConceptScore W2416615002C2776914184 @default.
• W2416615002 hasConceptScore W2416615002C2777714996 @default.
• W2416615002 hasConceptScore W2416615002C2778786243 @default.
• W2416615002 hasConceptScore W2416615002C2779726688 @default.
• W2416615002 hasConceptScore W2416615002C2781005078 @default.
• W2416615002 hasConceptScore W2416615002C55493867 @default.
• W2416615002 hasConceptScore W2416615002C71924100 @default.
• W2416615002 hasIssue "1" @default.
• W2416615002 hasLocation W24166150021 @default.
• W2416615002 hasOpenAccess W2416615002 @default.
• W2416615002 hasPrimaryLocation W24166150021 @default.
• W2416615002 hasRelatedWork W1906248643 @default.
• W2416615002 hasRelatedWork W1988960137 @default.
• W2416615002 hasRelatedWork W2012012488 @default.
• W2416615002 hasRelatedWork W2043505088 @default.
• W2416615002 hasRelatedWork W2069039175 @default.
• W2416615002 hasRelatedWork W2076838496 @default.
• W2416615002 hasRelatedWork W2080207433 @default.
• W2416615002 hasRelatedWork W2121274267 @default.
• W2416615002 hasRelatedWork W2139188664 @default.
• W2416615002 hasRelatedWork W2416679579 @default.
• W2416615002 hasVolume "68" @default.
• W2416615002 isParatext "false" @default.
• W2416615002 isRetracted "false" @default.
• W2416615002 magId "2416615002" @default.
• W2416615002 workType "article" @default.