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- W2416631657 abstract "Aim To study the effects of protease inhibitors on the large and small intestinal ab sorption of insulin in rats and to explore the mechanism of various protease inh ibitors in different intestinal regions. Methods The intestinal absorption of insulin was evaluated by its hypoglycemic effect an d serum insulin level using an in situ loop method with the washing treatmen t. Results Administration of insulin alone did not decrease the glucose level at either int estinal region with or without the washing treatment. With the unwashing treatme nt, there were no hypoglycemic effects in small intestinal loop when coadministr ation of insulin with protease inhibitors. With the washing treatment, the biolo gical effects of insulin were amplified a little in small intestinal loop; obvi ous hypoglycemic effects were found in large intestinal loop with or without th e washing treatment. The effectiveness of protease inhibitors was susceptible to their categories, concentrations and activities of proteolytic enzymes in diffe rent regions. The efficacy order of various protease inhibitors for enhancing hy poglycemic response of insulin was: leupeptin sodium glycocholate bacitracin bestatin cystatin; the percutaneous enhancement effects were observed in th e presence of either sodium glycocholate or bacitracin. Conclusion Coadministration of protease inhibitors could increase the insulin efficacy more effectively in the large intestine than in the small intestine." @default.
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- W2416631657 date "2004-02-01" @default.
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- W2416631657 title "Effects of protease inhibitors on intestinal absorption of insulin" @default.
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