Matches in SemOpenAlex for { <https://semopenalex.org/work/W2416645852> ?p ?o ?g. }
- W2416645852 endingPage "95" @default.
- W2416645852 startingPage "86" @default.
- W2416645852 abstract "Purpose of review Sensing of nutrients and microbes in the gut are fundamental processes necessary for life. This review aims to provide an overview of the basic background and new data on cellular nutrient, energy, and microbe sensors. Recent findings The nutrient sensors 5’ adenosine monophosphate-activated protein kinase, activating transcription factor 4 and mechanistic target of rapamycin (mTOR) are critical in control of the cell cycle. Recent data demonstrate their role in metabolic syndrome, in cell growth, and as therapeutic targets. Regulation of mTOR by the amino acids is the subject of intense investigation. Recent studies have further elucidated the exact mechanism of amino acid-dependent mTOR regulation. Pathogen recognition receptors (PRRs) are receptors that recognize conserved microbial molecules. New data demonstrate how lymphocyte-specific PRRs are necessary to maintain homeostasis. Moreover, new studies explore the role of PRRs in controlling the gut bacterial and fungal microbiome. Summary Nutrient sensing molecules are central to cell growth and metabolism and are implicated in cancer and the metabolic syndrome. Regulation of nutrient sensors is complex, and may be amenable to therapeutic targeting. Microbial sensors play critical roles in homeostasis and maintenance of the gut fungal and bacterial microbiome." @default.
- W2416645852 created "2016-06-24" @default.
- W2416645852 creator A5035200249 @default.
- W2416645852 date "2016-03-01" @default.
- W2416645852 modified "2023-09-27" @default.
- W2416645852 title "Sensing of nutrients and microbes in the gut" @default.
- W2416645852 cites W1524848610 @default.
- W2416645852 cites W1526556216 @default.
- W2416645852 cites W1531386034 @default.
- W2416645852 cites W1579566330 @default.
- W2416645852 cites W1670573097 @default.
- W2416645852 cites W1952608506 @default.
- W2416645852 cites W1963651279 @default.
- W2416645852 cites W1971597300 @default.
- W2416645852 cites W1973646620 @default.
- W2416645852 cites W1975517035 @default.
- W2416645852 cites W1979217507 @default.
- W2416645852 cites W1980195461 @default.
- W2416645852 cites W1993506872 @default.
- W2416645852 cites W1995586746 @default.
- W2416645852 cites W1995924556 @default.
- W2416645852 cites W1998389471 @default.
- W2416645852 cites W1999928395 @default.
- W2416645852 cites W2004465286 @default.
- W2416645852 cites W2014177895 @default.
- W2416645852 cites W2016752484 @default.
- W2416645852 cites W2017237017 @default.
- W2416645852 cites W2026097830 @default.
- W2416645852 cites W2032065353 @default.
- W2416645852 cites W2036743290 @default.
- W2416645852 cites W2044386584 @default.
- W2416645852 cites W2052708139 @default.
- W2416645852 cites W2062593620 @default.
- W2416645852 cites W2069296495 @default.
- W2416645852 cites W2079172266 @default.
- W2416645852 cites W2093524746 @default.
- W2416645852 cites W2100704940 @default.
- W2416645852 cites W2105738527 @default.
- W2416645852 cites W2106855445 @default.
- W2416645852 cites W2107387055 @default.
- W2416645852 cites W2110853277 @default.
- W2416645852 cites W2114079476 @default.
- W2416645852 cites W2127063807 @default.
- W2416645852 cites W2129374849 @default.
- W2416645852 cites W2141040025 @default.
- W2416645852 cites W2147044753 @default.
- W2416645852 cites W2157760261 @default.
- W2416645852 cites W2158732372 @default.
- W2416645852 cites W2167927725 @default.
- W2416645852 cites W2197815519 @default.
- W2416645852 cites W2206269655 @default.
- W2416645852 doi "https://doi.org/10.1097/mog.0000000000000246" @default.
- W2416645852 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26836123" @default.
- W2416645852 hasPublicationYear "2016" @default.
- W2416645852 type Work @default.
- W2416645852 sameAs 2416645852 @default.
- W2416645852 citedByCount "5" @default.
- W2416645852 countsByYear W24166458522019 @default.
- W2416645852 countsByYear W24166458522020 @default.
- W2416645852 countsByYear W24166458522022 @default.
- W2416645852 countsByYear W24166458522023 @default.
- W2416645852 crossrefType "journal-article" @default.
- W2416645852 hasAuthorship W2416645852A5035200249 @default.
- W2416645852 hasConcept C143121216 @default.
- W2416645852 hasConcept C170493617 @default.
- W2416645852 hasConcept C2491326 @default.
- W2416645852 hasConcept C2776030549 @default.
- W2416645852 hasConcept C2777949483 @default.
- W2416645852 hasConcept C55493867 @default.
- W2416645852 hasConcept C60644358 @default.
- W2416645852 hasConcept C62478195 @default.
- W2416645852 hasConcept C70721500 @default.
- W2416645852 hasConcept C86554907 @default.
- W2416645852 hasConcept C86803240 @default.
- W2416645852 hasConcept C95444343 @default.
- W2416645852 hasConceptScore W2416645852C143121216 @default.
- W2416645852 hasConceptScore W2416645852C170493617 @default.
- W2416645852 hasConceptScore W2416645852C2491326 @default.
- W2416645852 hasConceptScore W2416645852C2776030549 @default.
- W2416645852 hasConceptScore W2416645852C2777949483 @default.
- W2416645852 hasConceptScore W2416645852C55493867 @default.
- W2416645852 hasConceptScore W2416645852C60644358 @default.
- W2416645852 hasConceptScore W2416645852C62478195 @default.
- W2416645852 hasConceptScore W2416645852C70721500 @default.
- W2416645852 hasConceptScore W2416645852C86554907 @default.
- W2416645852 hasConceptScore W2416645852C86803240 @default.
- W2416645852 hasConceptScore W2416645852C95444343 @default.
- W2416645852 hasIssue "2" @default.
- W2416645852 hasLocation W24166458521 @default.
- W2416645852 hasLocation W24166458522 @default.
- W2416645852 hasOpenAccess W2416645852 @default.
- W2416645852 hasPrimaryLocation W24166458521 @default.
- W2416645852 hasRelatedWork W2002636911 @default.
- W2416645852 hasRelatedWork W2004976128 @default.
- W2416645852 hasRelatedWork W2024621655 @default.
- W2416645852 hasRelatedWork W2036681631 @default.
- W2416645852 hasRelatedWork W2041655266 @default.
- W2416645852 hasRelatedWork W2106568257 @default.