Matches in SemOpenAlex for { <https://semopenalex.org/work/W2416689095> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W2416689095 endingPage "22" @default.
- W2416689095 startingPage "313" @default.
- W2416689095 abstract "It is well known that glutamate receptors have significant role in the pain transmission. The activation of N-methyl-D-aspartate receptors causes persistent pain, therefore the antagonists acting on these receptors cause antinociception in chronic pain states. As the synthetic N-methyl-D-aspartate receptor antagonists have several side effects, they are not used generally in the clinical therapy. The tryptophan metabolite kynurenic acid is an endogenous antagonist of N-methyl-D-aspartate receptors. Although some data proved its neuroprotective effect, only a few studies suggest the antinociceptive potential of kynurenic acid. The goal of this review to summarise the possible role of kynurenic acid in the pain therapy based on the results of animal studies. Data available concerning this subject demonstrated that kynurenic acid is not an appropriate agent for antinociception neither in single nor in continuous administration because of its side-effect resulting in motor deficiency. On the other hand the combination of low doses of kynurenic acid and endomorphin-1 provides effective antinociception without side-effects on inflammatory pain test, thus may offer a new treatment modality in human pain therapy." @default.
- W2416689095 created "2016-06-24" @default.
- W2416689095 creator A5009424616 @default.
- W2416689095 creator A5055362431 @default.
- W2416689095 date "2002-09-20" @default.
- W2416689095 modified "2023-09-23" @default.
- W2416689095 title "[Analgesic effect of kynurenic acid]." @default.
- W2416689095 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12503245" @default.
- W2416689095 hasPublicationYear "2002" @default.
- W2416689095 type Work @default.
- W2416689095 sameAs 2416689095 @default.
- W2416689095 citedByCount "2" @default.
- W2416689095 crossrefType "journal-article" @default.
- W2416689095 hasAuthorship W2416689095A5009424616 @default.
- W2416689095 hasAuthorship W2416689095A5055362431 @default.
- W2416689095 hasConcept C126322002 @default.
- W2416689095 hasConcept C15490471 @default.
- W2416689095 hasConcept C170493617 @default.
- W2416689095 hasConcept C185592680 @default.
- W2416689095 hasConcept C25498285 @default.
- W2416689095 hasConcept C2776706248 @default.
- W2416689095 hasConcept C2776841986 @default.
- W2416689095 hasConcept C2776885963 @default.
- W2416689095 hasConcept C2777503454 @default.
- W2416689095 hasConcept C2780820201 @default.
- W2416689095 hasConcept C515207424 @default.
- W2416689095 hasConcept C55493867 @default.
- W2416689095 hasConcept C61174792 @default.
- W2416689095 hasConcept C71924100 @default.
- W2416689095 hasConcept C98274493 @default.
- W2416689095 hasConceptScore W2416689095C126322002 @default.
- W2416689095 hasConceptScore W2416689095C15490471 @default.
- W2416689095 hasConceptScore W2416689095C170493617 @default.
- W2416689095 hasConceptScore W2416689095C185592680 @default.
- W2416689095 hasConceptScore W2416689095C25498285 @default.
- W2416689095 hasConceptScore W2416689095C2776706248 @default.
- W2416689095 hasConceptScore W2416689095C2776841986 @default.
- W2416689095 hasConceptScore W2416689095C2776885963 @default.
- W2416689095 hasConceptScore W2416689095C2777503454 @default.
- W2416689095 hasConceptScore W2416689095C2780820201 @default.
- W2416689095 hasConceptScore W2416689095C515207424 @default.
- W2416689095 hasConceptScore W2416689095C55493867 @default.
- W2416689095 hasConceptScore W2416689095C61174792 @default.
- W2416689095 hasConceptScore W2416689095C71924100 @default.
- W2416689095 hasConceptScore W2416689095C98274493 @default.
- W2416689095 hasIssue "9-10" @default.
- W2416689095 hasLocation W24166890951 @default.
- W2416689095 hasOpenAccess W2416689095 @default.
- W2416689095 hasPrimaryLocation W24166890951 @default.
- W2416689095 hasRelatedWork W1567364235 @default.
- W2416689095 hasRelatedWork W1983125937 @default.
- W2416689095 hasRelatedWork W2028601586 @default.
- W2416689095 hasRelatedWork W2031053532 @default.
- W2416689095 hasRelatedWork W2106566895 @default.
- W2416689095 hasRelatedWork W2167224636 @default.
- W2416689095 hasRelatedWork W2339537085 @default.
- W2416689095 hasRelatedWork W2416689095 @default.
- W2416689095 hasRelatedWork W2601140729 @default.
- W2416689095 hasRelatedWork W488235 @default.
- W2416689095 hasVolume "55" @default.
- W2416689095 isParatext "false" @default.
- W2416689095 isRetracted "false" @default.
- W2416689095 magId "2416689095" @default.
- W2416689095 workType "article" @default.