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- W2416707029 abstract "Clinical studies have demonstrated that the antidepressant efficacy of Hypericum perforatum extract is comparable to that of classic antidepressants, such as imipramine. The role played by its components, particularly hypericin and hyperforin, has been examined in different experimental models of depression. The present study was carried out in order to verify the hypothesis that hyperforin is the main active antidepressant component. For this purpose we evaluated the activity of a dry extract from a subspecies of H. perforatum, H. perforatum spp. angustifolium, which has a higher hyperforin content than H. perforatum perforatum, in a series of experimental models of depression. The models used are based on the development of hyporeactivity to aversive stimuli induced by unavoidable stress exposure in rats. The extract of H. perforatum angustifolium presented an efficacy that was similar to that obtained with a treatment with imipramine or H. perforatum perforatum. Furthermore, in the models used the H. perforatum angustifolium extract was active at doses eight times lower than those necessary to produce a comparable activity with H. perforatum extract." @default.
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- W2416707029 date "2003-11-01" @default.
- W2416707029 modified "2023-10-16" @default.
- W2416707029 title "<i>Hypericum perforatum</i>Subspecies<i>Angustifolium</i>shows a Protective Activity on the Consequences of Unavoidable Stress Exposure at Lower Doses than<i>Hypericum perforatum Perforatum</i>" @default.
- W2416707029 doi "https://doi.org/10.1055/s-2003-45114" @default.
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