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• W2416713039 abstract "Objective The objective of the study was to investigate the relationship between structural connectivity ( SC ) and functional connectivity ( FC ) in the cingulum in bipolar disorder ( BD ) and its various phases. Method We combined resting‐state functional magnetic resonance imaging and probabilistic tractographic diffusion tensor imaging to investigate FC and SC of the cingulum and its portions, the SC – FC relationship, and their correlations with clinical and neurocognitive measures on sustained attention in manic ( n = 21), depressed ( n = 20), and euthymic ( n = 20) bipolar patients and healthy controls ( HC ) ( n = 42). Results First, we found decreased FC between the anterior and posterior parts of the cingulum in manic patients when compared to depressed patients and HC . Second, we observed decreased SC of the cingulum bundle, particularly in its anterior part, in manic patients when compared to HC . Finally, alterations in the cingulum FC (but not SC ) correlated with clinical severity scores while changes in the cingulum SC (but not FC ) were related with neurocognitive deficits in sustained attention in BD . Conclusion We demonstrate for the first time a reduction in FC and concomitantly in SC of the cingulum in mania, which correlated with psychopathological and neurocognitive parameters, respectively, in BD . This supports the central role of cingulum connectivity specifically in mania." @default.
• W2416713039 created "2016-06-24" @default.
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• W2416713039 date "2016-06-07" @default.
• W2416713039 modified "2023-10-12" @default.
• W2416713039 title "Abnormal functional-structural cingulum connectivity in mania: combined functional magnetic resonance imaging-diffusion tensor imaging investigation in different phases of bipolar disorder" @default.
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• W2416713039 doi "https://doi.org/10.1111/acps.12596" @default.
• W2416713039 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27273612" @default.
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