Matches in SemOpenAlex for { <https://semopenalex.org/work/W2416720816> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W2416720816 endingPage "4" @default.
- W2416720816 startingPage "290" @default.
- W2416720816 abstract "Anti-beta 2 microglobulin sera (beta2m AS) rendered specific after extensive absorptions were obtained following immunization of rabbits with highly purified beta2m prepared from urine of tubular proteinuria. beta2m AS were cytotoxic upon addition of selected rabbit complement for human T and B lymphocytes. Partial inhibition of sheep red blood cells receptor recognition on T lymphocytes (E rosettes) and C3 component recognition on B lymphocytes (EAC rosettes) was obtained only with high concentrations of Fab'2 anti-beta2m, eliminating a direct association of beta2m and those receptors. Fab'2 anti-beta2 induced very little inhibition of Fc portion receptor recognition (EA rosettes), but they had no effect on lysis of targets covered with IgG anti-targets (ADCC), a function mediated through that receptor. Anti-beta2m antibodies in excess inhibited antigen-induced proliferation (PPD) and the mixed lymphocyte reaction (MLR) performed in AB serum and fetal calf serum containing media ; whereas a potentiation of the response occurred in the presence of an antigen excess (beta2m) brought by the culture medium (AB serum) suggesting involvement of immune complexes. Pretreatment of responding cells with beta2m AS did block unilateral MLR ; conversely, treatement of stimulating cells had no effect. Independent migration of T cell membrane antigens (HTLA) and beta2m upon addition of suitable ligands, as well as the lack of inhibition by Fab'2 anti-beta2m of complement dependent lysis with IgG anti-HTLA, excluded possible association of HTLA and beta2m." @default.
- W2416720816 created "2016-06-24" @default.
- W2416720816 creator A5002329986 @default.
- W2416720816 creator A5004940928 @default.
- W2416720816 creator A5008701020 @default.
- W2416720816 creator A5028122476 @default.
- W2416720816 date "1978-09-01" @default.
- W2416720816 modified "2023-09-26" @default.
- W2416720816 title "[Study of lymphocyte membrane antigens and receptors with antibodies to beta2-microglobulin (author's transl)]." @default.
- W2416720816 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/83567" @default.
- W2416720816 hasPublicationYear "1978" @default.
- W2416720816 type Work @default.
- W2416720816 sameAs 2416720816 @default.
- W2416720816 citedByCount "0" @default.
- W2416720816 crossrefType "journal-article" @default.
- W2416720816 hasAuthorship W2416720816A5002329986 @default.
- W2416720816 hasAuthorship W2416720816A5004940928 @default.
- W2416720816 hasAuthorship W2416720816A5008701020 @default.
- W2416720816 hasAuthorship W2416720816A5028122476 @default.
- W2416720816 hasConcept C147483822 @default.
- W2416720816 hasConcept C153911025 @default.
- W2416720816 hasConcept C154317977 @default.
- W2416720816 hasConcept C159654299 @default.
- W2416720816 hasConcept C170493617 @default.
- W2416720816 hasConcept C185592680 @default.
- W2416720816 hasConcept C202751555 @default.
- W2416720816 hasConcept C203014093 @default.
- W2416720816 hasConcept C21957315 @default.
- W2416720816 hasConcept C55493867 @default.
- W2416720816 hasConcept C86803240 @default.
- W2416720816 hasConceptScore W2416720816C147483822 @default.
- W2416720816 hasConceptScore W2416720816C153911025 @default.
- W2416720816 hasConceptScore W2416720816C154317977 @default.
- W2416720816 hasConceptScore W2416720816C159654299 @default.
- W2416720816 hasConceptScore W2416720816C170493617 @default.
- W2416720816 hasConceptScore W2416720816C185592680 @default.
- W2416720816 hasConceptScore W2416720816C202751555 @default.
- W2416720816 hasConceptScore W2416720816C203014093 @default.
- W2416720816 hasConceptScore W2416720816C21957315 @default.
- W2416720816 hasConceptScore W2416720816C55493867 @default.
- W2416720816 hasConceptScore W2416720816C86803240 @default.
- W2416720816 hasIssue "6" @default.
- W2416720816 hasLocation W24167208161 @default.
- W2416720816 hasOpenAccess W2416720816 @default.
- W2416720816 hasPrimaryLocation W24167208161 @default.
- W2416720816 hasRelatedWork W1570611950 @default.
- W2416720816 hasRelatedWork W1973296161 @default.
- W2416720816 hasRelatedWork W19856627 @default.
- W2416720816 hasRelatedWork W2008949385 @default.
- W2416720816 hasRelatedWork W2018466012 @default.
- W2416720816 hasRelatedWork W2040191638 @default.
- W2416720816 hasRelatedWork W2079497707 @default.
- W2416720816 hasRelatedWork W33508033 @default.
- W2416720816 hasRelatedWork W339756260 @default.
- W2416720816 hasRelatedWork W940191291 @default.
- W2416720816 hasVolume "26" @default.
- W2416720816 isParatext "false" @default.
- W2416720816 isRetracted "false" @default.
- W2416720816 magId "2416720816" @default.
- W2416720816 workType "article" @default.