Matches in SemOpenAlex for { <https://semopenalex.org/work/W2416729059> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2416729059 endingPage "14" @default.
- W2416729059 startingPage "207" @default.
- W2416729059 abstract "To construct a three-dimensional (3D) model of histidine kinase (HK) YycG protein in Streptococcus pneumoniae and to investigate the interaction between YycG and its substrate ADP for the purpose of providing a theoretical basis for YycG selective inhibitor discovery, we constructed a 3D model of YycG protein by homology modeling, and assessed the reliability of the model using ProCheck and Profile_3D software. Besides, the active-site cavity of YycG and the residues key for substrate interaction were analyzed by Autodock4.0. Sequence alignment indicated that the YycG of S. pneumoniae was homologous to that of Thermotoga maritima. The constructed 3D model of YycG adopted a similar folding pattern to the template and the two matched well. The conservative amino acids in the substrate-binding pocket, such as Asn145, Asn149 and Lys152, as well as the hydrophobic residues at the bottom of the pocket played important role in binding and hydrolyzing substrate ADP. We have successfully constructed a reliable model of YycG protein. The model can be used as a starting point for designing antibacterial drugs." @default.
- W2416729059 created "2016-06-24" @default.
- W2416729059 creator A5007495967 @default.
- W2416729059 creator A5015105154 @default.
- W2416729059 creator A5025996303 @default.
- W2416729059 creator A5033020983 @default.
- W2416729059 creator A5039484711 @default.
- W2416729059 creator A5059083216 @default.
- W2416729059 creator A5061576353 @default.
- W2416729059 creator A5086529957 @default.
- W2416729059 date "2009-02-01" @default.
- W2416729059 modified "2023-09-26" @default.
- W2416729059 title "[Histidine kinase (YycG) protein of Streptococcus pneumoniae: homology modeling and analysis]." @default.
- W2416729059 cites W1601146610 @default.
- W2416729059 cites W1650702909 @default.
- W2416729059 cites W1963867445 @default.
- W2416729059 cites W2024897938 @default.
- W2416729059 cites W2047300379 @default.
- W2416729059 cites W2081912151 @default.
- W2416729059 cites W2088407530 @default.
- W2416729059 cites W2106144388 @default.
- W2416729059 cites W2118585647 @default.
- W2416729059 cites W2130571780 @default.
- W2416729059 cites W2158658436 @default.
- W2416729059 cites W2165526004 @default.
- W2416729059 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19459325" @default.
- W2416729059 hasPublicationYear "2009" @default.
- W2416729059 type Work @default.
- W2416729059 sameAs 2416729059 @default.
- W2416729059 citedByCount "0" @default.
- W2416729059 crossrefType "journal-article" @default.
- W2416729059 hasAuthorship W2416729059A5007495967 @default.
- W2416729059 hasAuthorship W2416729059A5015105154 @default.
- W2416729059 hasAuthorship W2416729059A5025996303 @default.
- W2416729059 hasAuthorship W2416729059A5033020983 @default.
- W2416729059 hasAuthorship W2416729059A5039484711 @default.
- W2416729059 hasAuthorship W2416729059A5059083216 @default.
- W2416729059 hasAuthorship W2416729059A5061576353 @default.
- W2416729059 hasAuthorship W2416729059A5086529957 @default.
- W2416729059 hasConcept C165525559 @default.
- W2416729059 hasConcept C169627665 @default.
- W2416729059 hasConcept C181199279 @default.
- W2416729059 hasConcept C185592680 @default.
- W2416729059 hasConcept C200307862 @default.
- W2416729059 hasConcept C2778460671 @default.
- W2416729059 hasConcept C2778905257 @default.
- W2416729059 hasConcept C2781253189 @default.
- W2416729059 hasConcept C41183919 @default.
- W2416729059 hasConcept C47701112 @default.
- W2416729059 hasConcept C501593827 @default.
- W2416729059 hasConcept C515207424 @default.
- W2416729059 hasConcept C55493867 @default.
- W2416729059 hasConcept C70721500 @default.
- W2416729059 hasConcept C86803240 @default.
- W2416729059 hasConceptScore W2416729059C165525559 @default.
- W2416729059 hasConceptScore W2416729059C169627665 @default.
- W2416729059 hasConceptScore W2416729059C181199279 @default.
- W2416729059 hasConceptScore W2416729059C185592680 @default.
- W2416729059 hasConceptScore W2416729059C200307862 @default.
- W2416729059 hasConceptScore W2416729059C2778460671 @default.
- W2416729059 hasConceptScore W2416729059C2778905257 @default.
- W2416729059 hasConceptScore W2416729059C2781253189 @default.
- W2416729059 hasConceptScore W2416729059C41183919 @default.
- W2416729059 hasConceptScore W2416729059C47701112 @default.
- W2416729059 hasConceptScore W2416729059C501593827 @default.
- W2416729059 hasConceptScore W2416729059C515207424 @default.
- W2416729059 hasConceptScore W2416729059C55493867 @default.
- W2416729059 hasConceptScore W2416729059C70721500 @default.
- W2416729059 hasConceptScore W2416729059C86803240 @default.
- W2416729059 hasIssue "2" @default.
- W2416729059 hasLocation W24167290591 @default.
- W2416729059 hasOpenAccess W2416729059 @default.
- W2416729059 hasPrimaryLocation W24167290591 @default.
- W2416729059 hasRelatedWork W1496683870 @default.
- W2416729059 hasRelatedWork W1981687952 @default.
- W2416729059 hasRelatedWork W1988059453 @default.
- W2416729059 hasRelatedWork W1989016185 @default.
- W2416729059 hasRelatedWork W2001590171 @default.
- W2416729059 hasRelatedWork W2025414979 @default.
- W2416729059 hasRelatedWork W2029968439 @default.
- W2416729059 hasRelatedWork W2055249438 @default.
- W2416729059 hasRelatedWork W2057946823 @default.
- W2416729059 hasRelatedWork W2058442404 @default.
- W2416729059 hasRelatedWork W2074702480 @default.
- W2416729059 hasRelatedWork W2079740756 @default.
- W2416729059 hasRelatedWork W2172129711 @default.
- W2416729059 hasRelatedWork W2306009964 @default.
- W2416729059 hasRelatedWork W2436826569 @default.
- W2416729059 hasRelatedWork W2587412154 @default.
- W2416729059 hasRelatedWork W2765213740 @default.
- W2416729059 hasRelatedWork W2802437682 @default.
- W2416729059 hasRelatedWork W2945860259 @default.
- W2416729059 hasVolume "25" @default.
- W2416729059 isParatext "false" @default.
- W2416729059 isRetracted "false" @default.
- W2416729059 magId "2416729059" @default.
- W2416729059 workType "article" @default.