Matches in SemOpenAlex for { <https://semopenalex.org/work/W2416766237> ?p ?o ?g. }
- W2416766237 abstract "Following root avulsion, spinal nerves are physically disconnected from the spinal cord. Severe motoneuron death and inefficient axon regeneration often result in devastating motor dysfunction. Newly formed axons need to extend through inhibitory scar tissue at the CNS-PNS transitional zone before entering into a pro-regenerative peripheral nerve trajectory. CSPGs are dominant suppressors in scar tissue and exert inhibition via neuronal receptors including PTPσ. Previously, a small peptide memetic of the PTPσ wedge region named ISP (Intracellular Sigma Peptide) was generated, and its capabilities to target PTPσ and relieve CSPG inhibition were validated. Here, we demonstrate that after ventral root avulsion and immediate re-implantation, modulation of PTPσ by systemic delivery of ISP remarkably enhanced regeneration. ISP treatment reduced motoneuron death, increased the number of axons regenerating across scar tissue, rebuilt healthy neuromuscular junctions and enhanced motor functional recovery. Our study shows that modulation of PTPσ is a potential therapeutic strategy for root avulsion." @default.
- W2416766237 created "2016-06-24" @default.
- W2416766237 creator A5001728683 @default.
- W2416766237 creator A5001997941 @default.
- W2416766237 creator A5013795174 @default.
- W2416766237 creator A5043396522 @default.
- W2416766237 creator A5051151391 @default.
- W2416766237 creator A5051278575 @default.
- W2416766237 creator A5080932213 @default.
- W2416766237 creator A5084793403 @default.
- W2416766237 creator A5089711006 @default.
- W2416766237 date "2015-10-14" @default.
- W2416766237 modified "2023-10-01" @default.
- W2416766237 title "Enhanced regeneration and functional recovery after spinal root avulsion by manipulation of the proteoglycan receptor PTPσ" @default.
- W2416766237 cites W1702345633 @default.
- W2416766237 cites W1919911722 @default.
- W2416766237 cites W1966007526 @default.
- W2416766237 cites W1968534173 @default.
- W2416766237 cites W1975002537 @default.
- W2416766237 cites W1976795542 @default.
- W2416766237 cites W1982047183 @default.
- W2416766237 cites W1982302921 @default.
- W2416766237 cites W2004406599 @default.
- W2416766237 cites W2005378461 @default.
- W2416766237 cites W2012928251 @default.
- W2416766237 cites W2014312989 @default.
- W2416766237 cites W2014613295 @default.
- W2416766237 cites W2015253298 @default.
- W2416766237 cites W2016173791 @default.
- W2416766237 cites W2016720448 @default.
- W2416766237 cites W2019730170 @default.
- W2416766237 cites W2024744542 @default.
- W2416766237 cites W2024764478 @default.
- W2416766237 cites W2025527723 @default.
- W2416766237 cites W2034918199 @default.
- W2416766237 cites W2043930451 @default.
- W2416766237 cites W2047757988 @default.
- W2416766237 cites W2049332135 @default.
- W2416766237 cites W2062311693 @default.
- W2416766237 cites W2064969847 @default.
- W2416766237 cites W2065561134 @default.
- W2416766237 cites W2065608732 @default.
- W2416766237 cites W2069261633 @default.
- W2416766237 cites W2071526203 @default.
- W2416766237 cites W2073570398 @default.
- W2416766237 cites W2074701461 @default.
- W2416766237 cites W2076090817 @default.
- W2416766237 cites W2077403259 @default.
- W2416766237 cites W2086085796 @default.
- W2416766237 cites W2090771639 @default.
- W2416766237 cites W2091934940 @default.
- W2416766237 cites W2092357265 @default.
- W2416766237 cites W2096902307 @default.
- W2416766237 cites W2098942729 @default.
- W2416766237 cites W2099505205 @default.
- W2416766237 cites W2104968232 @default.
- W2416766237 cites W2108438047 @default.
- W2416766237 cites W2132392300 @default.
- W2416766237 cites W2151004988 @default.
- W2416766237 cites W2157650341 @default.
- W2416766237 cites W2322221951 @default.
- W2416766237 cites W4231006519 @default.
- W2416766237 doi "https://doi.org/10.1038/srep14923" @default.
- W2416766237 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4604492" @default.
- W2416766237 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26464223" @default.
- W2416766237 hasPublicationYear "2015" @default.
- W2416766237 type Work @default.
- W2416766237 sameAs 2416766237 @default.
- W2416766237 citedByCount "34" @default.
- W2416766237 countsByYear W24167662372017 @default.
- W2416766237 countsByYear W24167662372018 @default.
- W2416766237 countsByYear W24167662372019 @default.
- W2416766237 countsByYear W24167662372020 @default.
- W2416766237 countsByYear W24167662372021 @default.
- W2416766237 countsByYear W24167662372022 @default.
- W2416766237 countsByYear W24167662372023 @default.
- W2416766237 crossrefType "journal-article" @default.
- W2416766237 hasAuthorship W2416766237A5001728683 @default.
- W2416766237 hasAuthorship W2416766237A5001997941 @default.
- W2416766237 hasAuthorship W2416766237A5013795174 @default.
- W2416766237 hasAuthorship W2416766237A5043396522 @default.
- W2416766237 hasAuthorship W2416766237A5051151391 @default.
- W2416766237 hasAuthorship W2416766237A5051278575 @default.
- W2416766237 hasAuthorship W2416766237A5080932213 @default.
- W2416766237 hasAuthorship W2416766237A5084793403 @default.
- W2416766237 hasAuthorship W2416766237A5089711006 @default.
- W2416766237 hasBestOaLocation W24167662371 @default.
- W2416766237 hasConcept C105702510 @default.
- W2416766237 hasConcept C169760540 @default.
- W2416766237 hasConcept C171056886 @default.
- W2416766237 hasConcept C178409289 @default.
- W2416766237 hasConcept C2778334475 @default.
- W2416766237 hasConcept C2779530196 @default.
- W2416766237 hasConcept C2780775167 @default.
- W2416766237 hasConcept C37754001 @default.
- W2416766237 hasConcept C71924100 @default.
- W2416766237 hasConcept C86803240 @default.
- W2416766237 hasConcept C95444343 @default.
- W2416766237 hasConceptScore W2416766237C105702510 @default.
- W2416766237 hasConceptScore W2416766237C169760540 @default.