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• W2416785870 endingPage "130" @default.
• W2416785870 startingPage "123" @default.
• W2416785870 abstract "Studies on nerve conduits for peripheral nerve regeneration have concentrated on the manipulation of various conduit materials to avoid sacrificing native nerve in the clinical situation. With the proliferation of available nerve growth-stimulating factors, the focus is shifting experimentally toward molecular biologic manipulation, with the addition of these materials as substrates within the conduit. The clinical use of conduits has concentrated on the use of autogenous tissue, with a few examples of polyglactin (PGA) mesh and silicone. Ultimately, as yet, conduit material does not seem to have a profound effect on outcome. Substrate manipulation has not yet had clinical application. An important problem that remains, both experimentally and clinically, is overriding the size of the maximal gap that can be bridged successfully, as well as obtaining good functional sensory and motor recovery, compared with the use of nerve grafts. Advances in molecular biology may reveal further details about the nerve growth phenomenon, the precise sequencing of the substrate materials that are effective in promoting nerve growth, and when they should be applied. Advances in chemical engineering may provide additional biologically stable materials that have the ability to integrate growth-enhancing agents or factors into the lumen of the conduit." @default.
• W2416785870 created "2016-06-24" @default.
• W2416785870 creator A5021367587 @default.
• W2416785870 date "2000-02-01" @default.
• W2416785870 modified "2023-10-15" @default.
• W2416785870 title "USE OF NERVE CONDUITS IN PERIPHERAL NERVE REPAIR" @default.
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