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• W2416798753 abstract "No AccessJournal of Urology1 Jul 1988Contents and Effects of Substance P and Vasoactive Intestinal Polypeptide in the Bladder of Rats with and without Infravesical Outflow Obstruction P.O. Andersson, K.-E. Andersson, J. Fahrenkrug, A. Mattiasson, C. Sjögren, and B. Uvelius P.O. AnderssonP.O. Andersson More articles by this author , K.-E. AnderssonK.-E. Andersson More articles by this author , J. FahrenkrugJ. Fahrenkrug More articles by this author , A. MattiassonA. Mattiasson More articles by this author , C. SjögrenC. Sjögren More articles by this author , and B. UveliusB. Uvelius More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)41520-5AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail The concentrations of substance P and vasoactive intestinal polypeptide (VIP) were determined in the upper, middle, and lower part of the bladder of rats with and without intravesical outflow obstruction. In the obstructed animals there was a significant increase in bladder weight and the total amounts of substance P and VIP were increased. However, the concentrations of substance P were significantly lower than in the control bladders. The concentrations of VIP, on the other hand, were significantly higher in the middle and lower parts of obstructed bladders than in the controls. In isolated strips of the normal and obstructed bladders VIP had neither contractile nor relaxant effects. The peptide had no effect on electrically induced contractions. Substance P produced concentration-dependent contractions in both normal and obstructed bladders. However, obstructed bladders were significantly less sensitive than controls. It is concluded that the bladder instability seen in rats with infravesical outflow obstruction cannot be explained only in terms of changes in the bladder content of substance P or VIP. © 1988 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited BySteers W, Creedon D and Tuttle J (2018) Immunity to Nerve Growth Factor Prevents Afferent Plasticity Following Urinary Bladder HypertrophyJournal of Urology, VOL. 155, NO. 1, (379-385), Online publication date: 1-Jan-1996.Sullivan M and Yalla S (2018) Detrusor Contractility and Compliance Characteristics in Adult Male Patients With Obstructive and Nonobstructive Voiding DysfunctionJournal of Urology, VOL. 155, NO. 6, (1995-2000), Online publication date: 1-Jun-1996.Igawa Y, Mattiasson A and Andersson K (2018) Micturition and Premicturition Contractions in Unanesthetized Rats with Bladder Outlet ObstructionJournal of Urology, VOL. 151, NO. 1, (244-249), Online publication date: 1-Jan-1994.Berggren T, Andersson K, Lundin S and Uvelius B (2018) Effect and Content of Arginine Vasopressin in Normal and Obstructed Rat Urinary Bladder: An in Vivo and in Vitro InvestigationJournal of Urology, VOL. 150, NO. 5 Part 1, (1540-1543), Online publication date: 1-Nov-1993.Igawa Y, Persson K, Andersson K, Uvelius B and Mattiasson A (2018) Facilitatory Effect of Vasoactive Intestinal Polypeptide on Spinal and Peripheral Micturition Reflex Pathways in Conscious Rats with and without Detrusor InstabilityJournal of Urology, VOL. 149, NO. 4, (884-889), Online publication date: 1-Apr-1993.Malmgren A, Uvelius B, Andersson K and Andersson P (2018) On the Reversibility of Functional Bladder Changes Induced by Infra Vesical Outflow Obstruction in the RatJournal of Urology, VOL. 143, NO. 5, (1026-1031), Online publication date: 1-May-1990. Volume 140Issue 1July 1988Page: 168-172 Advertisement Copyright & Permissions© 1988 by The American Urological Association Education and Research, Inc.MetricsAuthor Information P.O. Andersson More articles by this author K.-E. Andersson More articles by this author J. Fahrenkrug More articles by this author A. Mattiasson More articles by this author C. Sjögren More articles by this author B. Uvelius More articles by this author Expand All Advertisement PDF DownloadLoading ..." @default.
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• W2416798753 title "Contents and Effects of Substance P and Vasoactive Intestinal Polypeptide in the Bladder of Rats with and without Infravesical Outflow Obstruction" @default.
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