FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2416821490> ?p ?o ?g. }

• W2416821490 abstract "Abstract Sodium taurocholate cotransporting polypeptide (NTCP) is a recently discovered hepatitis B virus (HBV) receptor. In the present study, we used TK-NOG mice with a humanized liver to examine the impact of endogenous NTCP expression on HBV infection. Upon inoculation with HBV, these mice exhibited clear viremia in 2 weeks and serum HBV DNA levels gradually increased. The frequency of HBsAg-positive hepatocytes in the liver was 5.1 ± 0.6% at 2 weeks and increased with increasing HBV DNA levels, reaching 92.9 ± 2.8% at 10 to 12 weeks. In vivo siRNA-mediated NTCP knockdown before and after HBV inoculation significantly suppressed the levels of HBV replication and the frequency of HBsAg-positive hepatocytes at 2 weeks, whereas NTCP knockdown 13 weeks after infection did not affect these parameters. Similar to the humanized mouse livers in the early phase of HBV infection, human liver samples from chronic hepatitis B patients, especially those treated with nucleos(t)ide analogues, contained a considerable number of hepatocytes that were negative for the anti-HBs antibody. In conclusion, NTCP inhibition prevents the spread of HBV-infected hepatocytes in mice with a humanized liver. NTCP-targeted therapy has potential for regulating HBV infection in patients with chronic hepatitis B." @default.
• W2416821490 created "2016-06-24" @default.
• W2416821490 creator A5004646439 @default.
• W2416821490 creator A5012628849 @default.
• W2416821490 creator A5020071687 @default.
• W2416821490 creator A5023392452 @default.
• W2416821490 creator A5024492796 @default.
• W2416821490 creator A5025882812 @default.
• W2416821490 creator A5027322897 @default.
• W2416821490 creator A5040891927 @default.
• W2416821490 creator A5043432956 @default.
• W2416821490 creator A5052190387 @default.
• W2416821490 creator A5056018649 @default.
• W2416821490 creator A5062035100 @default.
• W2416821490 creator A5071291796 @default.
• W2416821490 creator A5073472318 @default.
• W2416821490 creator A5088118861 @default.
• W2416821490 creator A5090507788 @default.
• W2416821490 date "2016-06-09" @default.
• W2416821490 modified "2023-09-27" @default.
• W2416821490 title "Sodium taurocholate cotransporting polypeptide inhibition efficiently blocks hepatitis B virus spread in mice with a humanized liver" @default.
• W2416821490 cites W1642879362 @default.
• W2416821490 cites W1969776963 @default.
• W2416821490 cites W1974999149 @default.
• W2416821490 cites W1977229182 @default.
• W2416821490 cites W1984472078 @default.
• W2416821490 cites W1984703667 @default.
• W2416821490 cites W1986388698 @default.
• W2416821490 cites W1995085389 @default.
• W2416821490 cites W1997270466 @default.
• W2416821490 cites W2010338556 @default.
• W2416821490 cites W2013759529 @default.
• W2416821490 cites W2016861292 @default.
• W2416821490 cites W2028215043 @default.
• W2416821490 cites W2036454342 @default.
• W2416821490 cites W2036955573 @default.
• W2416821490 cites W2041515126 @default.
• W2416821490 cites W2057367489 @default.
• W2416821490 cites W2061594530 @default.
• W2416821490 cites W2072227423 @default.
• W2416821490 cites W2083140818 @default.
• W2416821490 cites W2085917459 @default.
• W2416821490 cites W2088160623 @default.
• W2416821490 cites W2102090977 @default.
• W2416821490 cites W2107983386 @default.
• W2416821490 cites W2120426460 @default.
• W2416821490 cites W2123781724 @default.
• W2416821490 cites W2131291808 @default.
• W2416821490 cites W2147181811 @default.
• W2416821490 cites W2163574676 @default.
• W2416821490 cites W2190238122 @default.
• W2416821490 cites W612273651 @default.
• W2416821490 doi "https://doi.org/10.1038/srep27782" @default.
• W2416821490 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4899802" @default.
• W2416821490 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27278060" @default.
• W2416821490 hasPublicationYear "2016" @default.
• W2416821490 type Work @default.
• W2416821490 sameAs 2416821490 @default.
• W2416821490 citedByCount "20" @default.
• W2416821490 countsByYear W24168214902017 @default.
• W2416821490 countsByYear W24168214902018 @default.
• W2416821490 countsByYear W24168214902019 @default.
• W2416821490 countsByYear W24168214902020 @default.
• W2416821490 countsByYear W24168214902021 @default.
• W2416821490 countsByYear W24168214902022 @default.
• W2416821490 countsByYear W24168214902023 @default.
• W2416821490 crossrefType "journal-article" @default.
• W2416821490 hasAuthorship W2416821490A5004646439 @default.
• W2416821490 hasAuthorship W2416821490A5012628849 @default.
• W2416821490 hasAuthorship W2416821490A5020071687 @default.
• W2416821490 hasAuthorship W2416821490A5023392452 @default.
• W2416821490 hasAuthorship W2416821490A5024492796 @default.
• W2416821490 hasAuthorship W2416821490A5025882812 @default.
• W2416821490 hasAuthorship W2416821490A5027322897 @default.
• W2416821490 hasAuthorship W2416821490A5040891927 @default.
• W2416821490 hasAuthorship W2416821490A5043432956 @default.
• W2416821490 hasAuthorship W2416821490A5052190387 @default.
• W2416821490 hasAuthorship W2416821490A5056018649 @default.
• W2416821490 hasAuthorship W2416821490A5062035100 @default.
• W2416821490 hasAuthorship W2416821490A5071291796 @default.
• W2416821490 hasAuthorship W2416821490A5073472318 @default.
• W2416821490 hasAuthorship W2416821490A5088118861 @default.
• W2416821490 hasAuthorship W2416821490A5090507788 @default.
• W2416821490 hasBestOaLocation W24168214901 @default.
• W2416821490 hasConcept C140704245 @default.
• W2416821490 hasConcept C150903083 @default.
• W2416821490 hasConcept C159047783 @default.
• W2416821490 hasConcept C159654299 @default.
• W2416821490 hasConcept C173396325 @default.
• W2416821490 hasConcept C203014093 @default.
• W2416821490 hasConcept C207001950 @default.
• W2416821490 hasConcept C2522874641 @default.
• W2416821490 hasConcept C2776156784 @default.
• W2416821490 hasConcept C2776185481 @default.
• W2416821490 hasConcept C2777410769 @default.
• W2416821490 hasConcept C2780593183 @default.
• W2416821490 hasConcept C54355233 @default.
• W2416821490 hasConcept C71924100 @default.
• W2416821490 hasConcept C81885089 @default.
• W2416821490 hasConcept C86803240 @default.

• next