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- W2416906345 endingPage "1510" @default.
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- W2416906345 abstract "Initially identified inDrosophila melanogaster, the Hippo signaling pathway regulates organ size through modulation of cell proliferation, survival and differentiation. This pathway is evolutionarily conserved and canonical signaling involves a kinase cascade that phosphorylates and inhibits the downstream effector Yes-associated protein (YAP). Recent research has demonstrated a fundamental role of Hippo signaling in cardiac development, homeostasis, injury and regeneration, and remains the subject of intense investigation. However, 2 prominent members of this pathway, RASSF1A and Mst1, have been shown to influence heart function and stress responses through YAP-independent mechanisms. This review summarizes non-canonical targets of RASSF1A and Mst1 and discusses their role in the context of cardiac hypertrophy, autophagy, apoptosis and function. (Circ J 2016; 80: 1504-1510)." @default.
- W2416906345 created "2016-06-24" @default.
- W2416906345 creator A5030619594 @default.
- W2416906345 date "2016-01-01" @default.
- W2416906345 modified "2023-10-05" @default.
- W2416906345 title "Hippo Signaling in the Heart – Non-Canonical Pathways Impact Growth, Survival and Function –" @default.
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- W2416906345 doi "https://doi.org/10.1253/circj.cj-16-0426" @default.
- W2416906345 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27296131" @default.