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- W2416962647 abstract "To determine the dopaminergic system involvement in precipitated cannabinoid withdrawal syndrome.The dopamine D1 receptor antagonist SCH23390 or the dopamine D2 receptor antagonist sulpiride was administered to rats chronically treated with either delta 9-tetrahydrocannabinol (THC) or vehicle. Subjects were then injected with either SR141716A or vehicle and behavior was observed for 1 h.Administration of the cannabinoid receptor antagonist SR141716A to animals chronically treated with THC as described by Tsou et al (1995) produced a profound withdrawal syndrome. Treatment with dopamine antagonists did not attenuate cannabinoid precipitated withdrawal syndrome in THC tolerant animals while the agonists increased the syndrome.It is unlikely that the dopaminergic system plays a major role in mediating the behavioral aspects of the cannabinoid withdrawal syndrome." @default.
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- W2416962647 date "1999-12-01" @default.
- W2416962647 modified "2023-09-27" @default.
- W2416962647 title "Dopaminergic system does not play a major role in the precipitated cannabinoid withdrawal syndrome." @default.
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