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• W2416972016 abstract "The amyloid precursor protein (APP) is a single-span integral membrane protein whose C-terminal fragment C99 is cleaved within the transmembrane helix by γ-secretase. Cleavage produces various Aβ peptides that are linked to the etiology of Alzheimer's disease. The transmembrane helix is known to homodimerize in a sequence-specific manner, and considerable controversy about whether the homodimeric form of C99 is cleaved by γ-secretase exists. Here, we generated various covalent C99 homodimers via cross-linking at engineered cysteine residues. None of the homodimers was cleaved in vitro by purified γ-secretase, strongly suggesting that homodimerization protects C99 from cleavage." @default.
• W2416972016 created "2016-06-24" @default.
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• W2416972016 date "2015-09-29" @default.
• W2416972016 modified "2023-09-29" @default.
• W2416972016 title "Homodimerization Protects the Amyloid Precursor Protein C99 Fragment from Cleavage by γ-Secretase" @default.
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• W2416972016 doi "https://doi.org/10.1021/acs.biochem.5b00986" @default.
• W2416972016 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26403946" @default.
• W2416972016 hasPublicationYear "2015" @default.
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