Matches in SemOpenAlex for { <https://semopenalex.org/work/W2416986411> ?p ?o ?g. }
- W2416986411 endingPage "411" @default.
- W2416986411 startingPage "406" @default.
- W2416986411 abstract "Injury to the joint provokes a number of local pathophysiological changes, including synthesis of inflammatory cytokines, death of chondrocytes, breakdown of the extra-cellular matrix of cartilage, and reduced synthesis of matrix macromolecules. These processes combine to engender the subsequent development of post-traumatic osteoarthritis (PTOA). To prevent this from happening, it is necessary to inhibit these disparate responses to injury; given their heterogeneity, this is challenging. However, dexamethasone has the necessary pleiotropic properties required of a drug for this purpose. Using in vitro models, we have shown that low doses of dexamethasone sustain the synthesis of cartilage proteoglycans while inhibiting their breakdown after injurious compression in the presence or absence of inflammatory cytokines. Under these conditions, dexamethasone is non-toxic and maintains the viability of chondrocytes exposed chronically to such cytokines as interleukin (IL) -1, IL-6, and tumor necrosis factor-α. Moreover, the anti-inflammatory properties of dexamethasone have been appreciated for decades. In view of this information, we have initiated a pilot clinical study to determine whether a single, intra-articular injection of dexamethasone into the wrist shows promise in preventing PTOA after intra-articular fracture of the distal radius.Suppressing the various etiopathophysiological responses to injury in the joint is an attractive strategy for lowering the clinical burden of PTOA. The intra-articular administration of dexamethasone soon after injury offers a simple and inexpensive means of accomplishing this. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:406-411, 2017." @default.
- W2416986411 created "2016-06-24" @default.
- W2416986411 creator A5002285513 @default.
- W2416986411 creator A5003642180 @default.
- W2416986411 creator A5003974495 @default.
- W2416986411 creator A5010640380 @default.
- W2416986411 creator A5030175305 @default.
- W2416986411 date "2017-03-01" @default.
- W2416986411 modified "2023-10-17" @default.
- W2416986411 title "Intra-articular dexamethasone to inhibit the development of post-traumatic osteoarthritis" @default.
- W2416986411 cites W1038569680 @default.
- W2416986411 cites W1561924353 @default.
- W2416986411 cites W1594591001 @default.
- W2416986411 cites W1596537893 @default.
- W2416986411 cites W1615432648 @default.
- W2416986411 cites W179053432 @default.
- W2416986411 cites W1860817203 @default.
- W2416986411 cites W1968388360 @default.
- W2416986411 cites W1988038353 @default.
- W2416986411 cites W1989433377 @default.
- W2416986411 cites W1992999163 @default.
- W2416986411 cites W1993523958 @default.
- W2416986411 cites W1994256020 @default.
- W2416986411 cites W2019909260 @default.
- W2416986411 cites W2021262572 @default.
- W2416986411 cites W2021954611 @default.
- W2416986411 cites W2032108983 @default.
- W2416986411 cites W2035972979 @default.
- W2416986411 cites W2039590395 @default.
- W2416986411 cites W2041233125 @default.
- W2416986411 cites W2042967685 @default.
- W2416986411 cites W2045206656 @default.
- W2416986411 cites W2048037026 @default.
- W2416986411 cites W2048310808 @default.
- W2416986411 cites W2056001843 @default.
- W2416986411 cites W2070382690 @default.
- W2416986411 cites W2074403367 @default.
- W2416986411 cites W2079295507 @default.
- W2416986411 cites W2095028617 @default.
- W2416986411 cites W2099246185 @default.
- W2416986411 cites W2101390983 @default.
- W2416986411 cites W2103767073 @default.
- W2416986411 cites W2104140369 @default.
- W2416986411 cites W2108434819 @default.
- W2416986411 cites W2110787997 @default.
- W2416986411 cites W2111110563 @default.
- W2416986411 cites W2111228339 @default.
- W2416986411 cites W2119666961 @default.
- W2416986411 cites W2143461769 @default.
- W2416986411 cites W2160374814 @default.
- W2416986411 cites W2167037356 @default.
- W2416986411 cites W2170117497 @default.
- W2416986411 cites W2408909958 @default.
- W2416986411 doi "https://doi.org/10.1002/jor.23295" @default.
- W2416986411 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5604325" @default.
- W2416986411 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27176565" @default.
- W2416986411 hasPublicationYear "2017" @default.
- W2416986411 type Work @default.
- W2416986411 sameAs 2416986411 @default.
- W2416986411 citedByCount "60" @default.
- W2416986411 countsByYear W24169864112016 @default.
- W2416986411 countsByYear W24169864112017 @default.
- W2416986411 countsByYear W24169864112018 @default.
- W2416986411 countsByYear W24169864112019 @default.
- W2416986411 countsByYear W24169864112020 @default.
- W2416986411 countsByYear W24169864112021 @default.
- W2416986411 countsByYear W24169864112022 @default.
- W2416986411 countsByYear W24169864112023 @default.
- W2416986411 crossrefType "journal-article" @default.
- W2416986411 hasAuthorship W2416986411A5002285513 @default.
- W2416986411 hasAuthorship W2416986411A5003642180 @default.
- W2416986411 hasAuthorship W2416986411A5003974495 @default.
- W2416986411 hasAuthorship W2416986411A5010640380 @default.
- W2416986411 hasAuthorship W2416986411A5030175305 @default.
- W2416986411 hasBestOaLocation W24169864111 @default.
- W2416986411 hasConcept C105702510 @default.
- W2416986411 hasConcept C106487976 @default.
- W2416986411 hasConcept C126322002 @default.
- W2416986411 hasConcept C142724271 @default.
- W2416986411 hasConcept C164027704 @default.
- W2416986411 hasConcept C17991360 @default.
- W2416986411 hasConcept C185592680 @default.
- W2416986411 hasConcept C203014093 @default.
- W2416986411 hasConcept C204787440 @default.
- W2416986411 hasConcept C2776164576 @default.
- W2416986411 hasConcept C2776914184 @default.
- W2416986411 hasConcept C2778690821 @default.
- W2416986411 hasConcept C2780401358 @default.
- W2416986411 hasConcept C2780550940 @default.
- W2416986411 hasConcept C43617362 @default.
- W2416986411 hasConcept C60644358 @default.
- W2416986411 hasConcept C71924100 @default.
- W2416986411 hasConcept C74172505 @default.
- W2416986411 hasConcept C86803240 @default.
- W2416986411 hasConcept C98274493 @default.
- W2416986411 hasConceptScore W2416986411C105702510 @default.
- W2416986411 hasConceptScore W2416986411C106487976 @default.
- W2416986411 hasConceptScore W2416986411C126322002 @default.