FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2416999119> ?p ?o ?g. }

• W2416999119 endingPage "G726" @default.
• W2416999119 startingPage "G718" @default.
• W2416999119 abstract "The role of the cystic fibrosis transmembrane conductance regulator (CFTR) in cAMP-stimulated secretion across the murine duodenum was investigated. Serosal-to-mucosal flux of (J s→m, in μeq ⋅ cm−2 ⋅ h−1) and short-circuit current (I sc; in μeq ⋅ cm−2 ⋅ h−1) were measured by the pH stat method in duodenum from CFTR knockout [CFTR(−)] and normal [CFTR(+)] mice. Under control conditions, forskolin increased J s→m andI sc (+1.7 and +3.5, respectively) across the CFTR(+) but not CFTR(−) duodenum. Both the forskolin-stimulated ΔJ s→m and ΔI sc were abolished by the CFTR channel blocker 5-nitro-2-(3-phenylpropylamino)benzoate, whereas inhibition of luminal Cl−/ exchange by luminal Cl− removal or DIDS reduced theJ s→m by ∼18% without a consistent effect on the ΔI sc. Methazolamide also reduced theJ s→m by 39% but did not affect the ΔI sc. When carbonic anhydrase-dependent secretion was isolated by using a CO2-gassed, -free Ringer bath, forskolin stimulated the J s→m andI sc (+0.7 and +2.0, respectively) across CFTR(+) but not CFTR(−) duodenum. Under these conditions, luminal Cl− substitution or DIDS abolished theJ s→m but not the ΔI sc. It was concluded that cAMP-stimulated secretion across the duodenum involves 1) electrogenic secretion via a CFTR conductance and2) electroneutral secretion via a CFTR-dependent Cl−/ exchange process that is closely associated with the carbonic anhydrase activity of the epithelium." @default.
• W2416999119 created "2016-06-24" @default.
• W2416999119 creator A5000826412 @default.
• W2416999119 creator A5076738334 @default.
• W2416999119 date "1998-04-01" @default.
• W2416999119 modified "2023-10-14" @default.
• W2416999119 title "Dual role of CFTR in cAMP-stimulated HCO 3 − secretion across murine duodenum" @default.
• W2416999119 cites W1432669748 @default.
• W2416999119 cites W1543734962 @default.
• W2416999119 cites W1546960667 @default.
• W2416999119 cites W1880325323 @default.
• W2416999119 cites W1913770988 @default.
• W2416999119 cites W1967563623 @default.
• W2416999119 cites W1974682292 @default.
• W2416999119 cites W1981713483 @default.
• W2416999119 cites W1982796477 @default.
• W2416999119 cites W2015655328 @default.
• W2416999119 cites W2016417321 @default.
• W2416999119 cites W2017380246 @default.
• W2416999119 cites W2028171116 @default.
• W2416999119 cites W2036570301 @default.
• W2416999119 cites W2038701031 @default.
• W2416999119 cites W2043502964 @default.
• W2416999119 cites W2044594872 @default.
• W2416999119 cites W2050573110 @default.
• W2416999119 cites W2050840170 @default.
• W2416999119 cites W2077830910 @default.
• W2416999119 cites W2091117477 @default.
• W2416999119 cites W2118659250 @default.
• W2416999119 cites W2127920211 @default.
• W2416999119 cites W2170265384 @default.
• W2416999119 cites W2170637723 @default.
• W2416999119 cites W2177670197 @default.
• W2416999119 cites W2260255165 @default.
• W2416999119 cites W2415884639 @default.
• W2416999119 cites W2431702132 @default.
• W2416999119 cites W2885923890 @default.
• W2416999119 cites W766161978 @default.
• W2416999119 doi "https://doi.org/10.1152/ajpgi.1998.274.4.g718" @default.
• W2416999119 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9575854" @default.
• W2416999119 hasPublicationYear "1998" @default.
• W2416999119 type Work @default.
• W2416999119 sameAs 2416999119 @default.
• W2416999119 citedByCount "85" @default.
• W2416999119 countsByYear W24169991192012 @default.
• W2416999119 countsByYear W24169991192013 @default.
• W2416999119 countsByYear W24169991192014 @default.
• W2416999119 countsByYear W24169991192015 @default.
• W2416999119 countsByYear W24169991192016 @default.
• W2416999119 countsByYear W24169991192017 @default.
• W2416999119 countsByYear W24169991192018 @default.
• W2416999119 countsByYear W24169991192019 @default.
• W2416999119 countsByYear W24169991192020 @default.
• W2416999119 countsByYear W24169991192021 @default.
• W2416999119 crossrefType "journal-article" @default.
• W2416999119 hasAuthorship W2416999119A5000826412 @default.
• W2416999119 hasAuthorship W2416999119A5076738334 @default.
• W2416999119 hasConcept C12554922 @default.
• W2416999119 hasConcept C126322002 @default.
• W2416999119 hasConcept C134018914 @default.
• W2416999119 hasConcept C170493617 @default.
• W2416999119 hasConcept C181199279 @default.
• W2416999119 hasConcept C185592680 @default.
• W2416999119 hasConcept C2775914622 @default.
• W2416999119 hasConcept C2776809568 @default.
• W2416999119 hasConcept C2776938444 @default.
• W2416999119 hasConcept C2778428886 @default.
• W2416999119 hasConcept C2779276759 @default.
• W2416999119 hasConcept C2779533339 @default.
• W2416999119 hasConcept C3018436504 @default.
• W2416999119 hasConcept C41625074 @default.
• W2416999119 hasConcept C49039625 @default.
• W2416999119 hasConcept C55493867 @default.
• W2416999119 hasConcept C71924100 @default.
• W2416999119 hasConcept C86803240 @default.
• W2416999119 hasConceptScore W2416999119C12554922 @default.
• W2416999119 hasConceptScore W2416999119C126322002 @default.
• W2416999119 hasConceptScore W2416999119C134018914 @default.
• W2416999119 hasConceptScore W2416999119C170493617 @default.
• W2416999119 hasConceptScore W2416999119C181199279 @default.
• W2416999119 hasConceptScore W2416999119C185592680 @default.
• W2416999119 hasConceptScore W2416999119C2775914622 @default.
• W2416999119 hasConceptScore W2416999119C2776809568 @default.
• W2416999119 hasConceptScore W2416999119C2776938444 @default.
• W2416999119 hasConceptScore W2416999119C2778428886 @default.
• W2416999119 hasConceptScore W2416999119C2779276759 @default.
• W2416999119 hasConceptScore W2416999119C2779533339 @default.
• W2416999119 hasConceptScore W2416999119C3018436504 @default.
• W2416999119 hasConceptScore W2416999119C41625074 @default.
• W2416999119 hasConceptScore W2416999119C49039625 @default.
• W2416999119 hasConceptScore W2416999119C55493867 @default.
• W2416999119 hasConceptScore W2416999119C71924100 @default.
• W2416999119 hasConceptScore W2416999119C86803240 @default.
• W2416999119 hasIssue "4" @default.
• W2416999119 hasLocation W24169991191 @default.
• W2416999119 hasLocation W24169991192 @default.
• W2416999119 hasOpenAccess W2416999119 @default.
• W2416999119 hasPrimaryLocation W24169991191 @default.

• next