FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2417063322> ?p ?o ?g. }

• W2417063322 abstract "Renal angiomyolipomas (AMLs) can be of sporadic origin or associated with tuberous sclerosis (TS). TS-associated AMLs often present in childhood, tend to be bilateral and multiple, and often exhibit a faster growth rate with an increased risk of hemorrhage. Renal cryoablation is well described in adults, whereas experiences with adolescents and young adults are limited. We present here for the first time a series of renal AMLs within adolescents and young adults treated with laparoscopic assisted cryoablation (LCA).The aim was to evaluate whether LCA of AMLs in adolescents and young adults is a safe and feasible treatment modality.From October 2009 to September 2013 a total of five patients at our institution were diagnosed with AMLs requiring treatment. Four patients had TS and one had AML of sporadic origin, all five patients underwent LCA. Data were retrospectively collected by a systematic review of patient material and reassessment of renal imaging.The median age was 16 years (range 13-27 years). Eight AMLs with a median size of 3.9 cm (range 2.1-7.7 cm) were treated in five patients because of tumor size and rapid growth. Follow-up was a median 37 months (range 20-62 months), and all tumors showed a reduction in tumor size, and no regrowth was recognized (see summary table). The procedure was well tolerated, with only few perioperative complications and no postoperative complications.When considering the indication for treating AMLs, the origin (sporadic or TS associated) and size of the tumor are the decisive factors. To preserve renal function and prevent spontaneous hemorrhage caution should be intensified when tumors reach 4 cm, particularly if TS is present. After the diagnosis is established, patients should be monitored with renal imaging at regular intervals to identify rapid-growing tumors. As an alternative to current treatment modalities such as partial nephrectomy and super selective angioembolization, cryoablation is an emerging approach, although experience with pediatric patients is limited. For patients not requiring immediate surgery, pharmacological treatment with mTOR inhibitors is now being evaluated as an alternative treatment option or as neo-adjuvant therapy to ablative techniques.Prophylactic treatment of large or rapid growing AMLs with LCA appears to be a safe and feasible nephron-sparing approach in adolescents and young adults. The low perioperative complication rate and promising effect on outcome might allow treatment of subclinical AMLs in order to minimize the risk of potentially life-threatening complications and preserve renal function." @default.
• W2417063322 created "2016-06-24" @default.
• W2417063322 creator A5000546523 @default.
• W2417063322 creator A5011265107 @default.
• W2417063322 creator A5075142719 @default.
• W2417063322 creator A5078469940 @default.
• W2417063322 date "2016-12-01" @default.
• W2417063322 modified "2023-10-14" @default.
• W2417063322 title "Laparoscopic cryoablation of angiomyolipomas in adolescents and young adults: A report of four cases associated with tuberous sclerosis and 1 case of sporadic origin" @default.
• W2417063322 cites W128188259 @default.
• W2417063322 cites W1989884830 @default.
• W2417063322 cites W1989978153 @default.
• W2417063322 cites W2003860776 @default.
• W2417063322 cites W2019304803 @default.
• W2417063322 cites W2028018192 @default.
• W2417063322 cites W2035079060 @default.
• W2417063322 cites W2041372857 @default.
• W2417063322 cites W2043040977 @default.
• W2417063322 cites W2050790870 @default.
• W2417063322 cites W2051205860 @default.
• W2417063322 cites W2061415668 @default.
• W2417063322 cites W2072011119 @default.
• W2417063322 cites W2081570548 @default.
• W2417063322 cites W2092252786 @default.
• W2417063322 cites W2096998881 @default.
• W2417063322 cites W2110227067 @default.
• W2417063322 cites W2126571315 @default.
• W2417063322 cites W2145025118 @default.
• W2417063322 cites W2151006275 @default.
• W2417063322 cites W2167331698 @default.
• W2417063322 cites W2341157896 @default.
• W2417063322 cites W50282841 @default.
• W2417063322 cites W1999374863 @default.
• W2417063322 doi "https://doi.org/10.1016/j.jpurol.2016.03.018" @default.
• W2417063322 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27346068" @default.
• W2417063322 hasPublicationYear "2016" @default.
• W2417063322 type Work @default.
• W2417063322 sameAs 2417063322 @default.
• W2417063322 citedByCount "2" @default.
• W2417063322 countsByYear W24170633222017 @default.
• W2417063322 crossrefType "journal-article" @default.
• W2417063322 hasAuthorship W2417063322A5000546523 @default.
• W2417063322 hasAuthorship W2417063322A5011265107 @default.
• W2417063322 hasAuthorship W2417063322A5075142719 @default.
• W2417063322 hasAuthorship W2417063322A5078469940 @default.
• W2417063322 hasConcept C126322002 @default.
• W2417063322 hasConcept C126838900 @default.
• W2417063322 hasConcept C141071460 @default.
• W2417063322 hasConcept C205545832 @default.
• W2417063322 hasConcept C2777628079 @default.
• W2417063322 hasConcept C2778902805 @default.
• W2417063322 hasConcept C2778980267 @default.
• W2417063322 hasConcept C2779052135 @default.
• W2417063322 hasConcept C2780091579 @default.
• W2417063322 hasConcept C31174226 @default.
• W2417063322 hasConcept C71924100 @default.
• W2417063322 hasConceptScore W2417063322C126322002 @default.
• W2417063322 hasConceptScore W2417063322C126838900 @default.
• W2417063322 hasConceptScore W2417063322C141071460 @default.
• W2417063322 hasConceptScore W2417063322C205545832 @default.
• W2417063322 hasConceptScore W2417063322C2777628079 @default.
• W2417063322 hasConceptScore W2417063322C2778902805 @default.
• W2417063322 hasConceptScore W2417063322C2778980267 @default.
• W2417063322 hasConceptScore W2417063322C2779052135 @default.
• W2417063322 hasConceptScore W2417063322C2780091579 @default.
• W2417063322 hasConceptScore W2417063322C31174226 @default.
• W2417063322 hasConceptScore W2417063322C71924100 @default.
• W2417063322 hasLocation W24170633221 @default.
• W2417063322 hasLocation W24170633222 @default.
• W2417063322 hasOpenAccess W2417063322 @default.
• W2417063322 hasPrimaryLocation W24170633221 @default.
• W2417063322 hasRelatedWork W1987778813 @default.
• W2417063322 hasRelatedWork W2069458126 @default.
• W2417063322 hasRelatedWork W2092252786 @default.
• W2417063322 hasRelatedWork W2110227067 @default.
• W2417063322 hasRelatedWork W2232811545 @default.
• W2417063322 hasRelatedWork W2263032760 @default.
• W2417063322 hasRelatedWork W2394050781 @default.
• W2417063322 hasRelatedWork W2399245517 @default.
• W2417063322 hasRelatedWork W3209434943 @default.
• W2417063322 hasRelatedWork W2183954588 @default.
• W2417063322 isParatext "false" @default.
• W2417063322 isRetracted "false" @default.
• W2417063322 magId "2417063322" @default.
• W2417063322 workType "article" @default.