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• W2417067932 abstract "Aim: We compared the efficacy of methotrexate/vinblastine/doxorubicin/cisplatin (MVAC) versus gemcitabine/cisplatin in urothelial cancer and neoadjuvant chemotherapy (NACT) efficacy in variant histology (VH). Materials & methods: Radical cystectomy patients were retrospectively compared with those who received NACT. Factors associated with survival, pathologic complete response (pCR) and downstaging (pDS) were evaluated in multivariable models. Results: 9% of radical cystectomy patients (84/919) received NACT, with improved survival, pCR and pDS on both regimens. MVAC lead to higher pDS without an increase in pCR. On multivariable analysis, there was a nonsignificant increase in pDS with MVAC. NACT conferred similar responses in squamous and glandular differentiation VH. Conclusion: NACT was associated with improved survival, pCR and pDS. Furthermore, responses to NACT were not dependent on presence of VH." @default.
• W2417067932 created "2016-06-24" @default.
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• W2417067932 date "2016-08-01" @default.
• W2417067932 modified "2023-10-14" @default.
• W2417067932 title "Neoadjuvant chemotherapy in urothelial bladder cancer: impact of regimen and variant histology" @default.
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• W2417067932 doi "https://doi.org/10.2217/fon-2016-0056" @default.
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