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- W2417153436 abstract "We have used rodent models of de/dysmyelination to examine proliferation and differentiation of polydendrocytes (NG2 glial cells) by pulse-chase labelling with bromodeoxyuridine (BrdU). In white matter of normal mouse spinal cord, there was a 10-fold decline in proliferation of NG2 glial cells during the second postnatal week between postnatal day 10 (P10) and P18. At P18 more than 95% of the proliferating cells were NG2+. Survival studies in normal mice that received a single injection of BrdU at P18 revealed that more than 90% of the labelled cells differentiated into APC+ oligodendrocytes within 2 weeks. In the shiverer dysmyelinating mutant in which oligodendrocytes develop normally but cannot form compact myelin due to lack of myelin basic protein, there was a 4- to 6-fold increase in NG2 cell proliferation at ages between P18 and P60. BrdU pulse-chase labelling of shiverer spinal cord at P18 showed a prolonged time course of differentiation of cells that were proliferating at P18 and persistence of proliferated NG2 cells compared with wild type. In an acute demyelinating lesion of the spinal cord created by injection of lysophosphatidylcholine (LPC), pulse-chase labelling with BrdU revealed that BrdU-incorporated NG2 cells first appeared in a region surrounding the demyelinated area and were subsequently seen inside the lesion 1 week after lesioning. By 2 week post lesioning when remyelination had begun, most of the BrdU-labelled cells had lost NG2 expression and had become APC+ oligodendrocytes. These observations suggest that NG2 glial cells first proliferate outside the lesion and subsequently migrate into the lesion centre where they differentiate into mature remyelinating oligodendrocytes. The spatial and temporal pattern of NG2 cell differentiation coincides with that of up-regulation of the homeodomain transcription factor Nkx2.2 implicated in oligodendrocyte differentiation. These findings and the close contact between NG2 cell processes and the surface of myelinated axons observed by immunoelectron microscopy suggest that the extent of myelination provides a signal for NG2 cell proliferation and/or differentiation. Supported by NIH, National Multiple Sclerosis Society, and the Wadsworth Foundation (USA)." @default.
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- W2417153436 date "2004-12-01" @default.
- W2417153436 modified "2023-09-26" @default.
- W2417153436 title "2: Identity, differentiation, and morphology of polydendrocytes (NG2 glial cells)" @default.
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