FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2417243585> ?p ?o ?g. }

• W2417243585 endingPage "112" @default.
• W2417243585 startingPage "87" @default.
• W2417243585 abstract "Selenium is an essential trace element and, like all elements, present in many different compounds with unequivocal functions. This fact is only sporadically mentioned when recommended intake or supplementation is indicated just as selenium. In mammals, selenium is an integral part of selenoproteins as selenocysteine. Selenocysteine is formed from serine at the respective tRNA((ser)sec), a reaction that requires selenophosphate formed from selenide and ATP. Thus, only compounds that can be metabolized into selenide can serve as sources for selenoprotein biosynthesis. We therefore tested the ability of selenium compounds such as sodium selenite, methylseleninic acid (MeSeA), Se-methyl selenocysteine, and selenomethionine to increase the activity, protein, or mRNA levels of commonly used biomarkers of the selenium status, glutathione peroxidase-1 (GPx1) and thioredoxin reductase, and of putatively new biomarkers, selenoprotein W1 (SepW1), selenoprotein H, and selenoprotein 15 in three different cell lines. Selenite and MeSeA were most efficient in increasing all markers tested, whereas the other compounds had only marginal effects. Effects were higher in the noncancerous young adult mouse colon cells than in the cancer cell lines HepG2 and HT-29. At the protein level, SepW1 responded as well as GPx1 and at the mRNA level, even better. Thus, the outcome of selenium treatment strongly depends on the chemical form, the cell type, and the biomarker used for testing efficacy." @default.
• W2417243585 created "2016-06-24" @default.
• W2417243585 creator A5023023382 @default.
• W2417243585 creator A5037485994 @default.
• W2417243585 creator A5053733302 @default.
• W2417243585 creator A5056077897 @default.
• W2417243585 date "2013-01-01" @default.
• W2417243585 modified "2023-09-29" @default.
• W2417243585 title "Selenoprotein W as Biomarker for the Efficacy of Selenium Compounds to Act as Source for Selenoprotein Biosynthesis" @default.
• W2417243585 cites W1668286863 @default.
• W2417243585 cites W1850356032 @default.
• W2417243585 cites W1902187426 @default.
• W2417243585 cites W1965714550 @default.
• W2417243585 cites W1967879087 @default.
• W2417243585 cites W1970739279 @default.
• W2417243585 cites W1978690429 @default.
• W2417243585 cites W1980146573 @default.
• W2417243585 cites W1983380926 @default.
• W2417243585 cites W1993453294 @default.
• W2417243585 cites W1999010068 @default.
• W2417243585 cites W2000042269 @default.
• W2417243585 cites W2003018523 @default.
• W2417243585 cites W2005771748 @default.
• W2417243585 cites W2007355806 @default.
• W2417243585 cites W2010579598 @default.
• W2417243585 cites W2011864450 @default.
• W2417243585 cites W2011972654 @default.
• W2417243585 cites W2013131201 @default.
• W2417243585 cites W2017086844 @default.
• W2417243585 cites W2020420306 @default.
• W2417243585 cites W2020578456 @default.
• W2417243585 cites W2021679868 @default.
• W2417243585 cites W2025380334 @default.
• W2417243585 cites W2033101865 @default.
• W2417243585 cites W2035856746 @default.
• W2417243585 cites W2036043934 @default.
• W2417243585 cites W2042207947 @default.
• W2417243585 cites W2057993716 @default.
• W2417243585 cites W2059334541 @default.
• W2417243585 cites W2061886027 @default.
• W2417243585 cites W2063860588 @default.
• W2417243585 cites W2068836274 @default.
• W2417243585 cites W2070175783 @default.
• W2417243585 cites W2075786756 @default.
• W2417243585 cites W2090236466 @default.
• W2417243585 cites W2093402309 @default.
• W2417243585 cites W2094463376 @default.
• W2417243585 cites W2096806228 @default.
• W2417243585 cites W2097126610 @default.
• W2417243585 cites W2098908746 @default.
• W2417243585 cites W2100121792 @default.
• W2417243585 cites W2123252811 @default.
• W2417243585 cites W2125795133 @default.
• W2417243585 cites W2128862717 @default.
• W2417243585 cites W2146962699 @default.
• W2417243585 cites W2149005038 @default.
• W2417243585 cites W2151163976 @default.
• W2417243585 cites W2153424390 @default.
• W2417243585 cites W2163496089 @default.
• W2417243585 cites W2168163140 @default.
• W2417243585 cites W2328191227 @default.
• W2417243585 cites W4294216491 @default.
• W2417243585 cites W4295115868 @default.
• W2417243585 cites W53971307 @default.
• W2417243585 doi "https://doi.org/10.1016/b978-0-12-405882-8.00005-2" @default.
• W2417243585 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23830627" @default.
• W2417243585 hasPublicationYear "2013" @default.
• W2417243585 type Work @default.
• W2417243585 sameAs 2417243585 @default.
• W2417243585 citedByCount "35" @default.
• W2417243585 countsByYear W24172435852013 @default.
• W2417243585 countsByYear W24172435852014 @default.
• W2417243585 countsByYear W24172435852015 @default.
• W2417243585 countsByYear W24172435852016 @default.
• W2417243585 countsByYear W24172435852017 @default.
• W2417243585 countsByYear W24172435852018 @default.
• W2417243585 countsByYear W24172435852019 @default.
• W2417243585 countsByYear W24172435852020 @default.
• W2417243585 countsByYear W24172435852021 @default.
• W2417243585 countsByYear W24172435852022 @default.
• W2417243585 countsByYear W24172435852023 @default.
• W2417243585 crossrefType "book-chapter" @default.
• W2417243585 hasAuthorship W2417243585A5023023382 @default.
• W2417243585 hasAuthorship W2417243585A5037485994 @default.
• W2417243585 hasAuthorship W2417243585A5053733302 @default.
• W2417243585 hasAuthorship W2417243585A5056077897 @default.
• W2417243585 hasConcept C178790620 @default.
• W2417243585 hasConcept C181199279 @default.
• W2417243585 hasConcept C185592680 @default.
• W2417243585 hasConcept C203580378 @default.
• W2417243585 hasConcept C203663253 @default.
• W2417243585 hasConcept C2776087148 @default.
• W2417243585 hasConcept C2776414213 @default.
• W2417243585 hasConcept C2776841403 @default.
• W2417243585 hasConcept C2777737464 @default.
• W2417243585 hasConcept C2778760513 @default.
• W2417243585 hasConcept C2779201268 @default.
• W2417243585 hasConcept C3623737 @default.

• next