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- W2417265161 abstract "<h3>Introduction</h3> The beneficial of immunonutrition on overall morbidity and mortality remains uncertain. We undertook a systematic review to evaluate the effects of immune-enhancing enteral nutrition (IEN) in upper gastrointestinal (GI) surgery. <h3>Method</h3> Main electronic databases [MEDLINE via Pubmed, EMBASE, Scopus, Web of Knowledge, Cochrane Central Register of Controlled Trials (CENTRAL) and the Cochrane Library, and clinical trial registry (ClinicalTrial.gov)] were searched for studies reported clinical outcomes comparing standard enteral nutrition (SEN) and immunonutrition (IEN). The systematic review was conducted in accordance with the PRISMA guidelines and meta-analysis was analysed using fixed and random-effects models. <h3>Results</h3> Nineteen RCTs with a total of 2016 patients (1017 IEN and 999 SEN) were included in the final pooled analysis. IEN significantly reduced post-operative wound infection (risk ratio (RR) 0.69, 95% confidence interval (CI) 0.50 to 0.94). Although, the combined results showed that IEN had a shorter hospital stay (RR –2.51 days, 95% CI –3.47 to –1.55), there was significant heterogeneity observed across these studies. There was no statistically significant benefit on other post-operative morbidities of interest (e.g. anastomotic leak and pulmonary infection) and mortality. <h3>Conclusion</h3> IEN decreases wound infection rates and reduces length of stay. It can be recommended as routine nutritional support in upper GI surgery. <h3>Disclosure of interest</h3> None Declared." @default.
- W2417265161 created "2016-06-24" @default.
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- W2417265161 date "2015-06-01" @default.
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- W2417265161 title "PTH-161 The effects of immunonutrition in upper gastrointestinal surgery: a systematic review and meta-analysis" @default.
- W2417265161 doi "https://doi.org/10.1136/gutjnl-2015-309861.1049" @default.
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