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- W2417291010 abstract "Abstract Fibroblast growth factor 21 ( FGF21 ) gene expression is altered by a wide array of physiological, metabolic, and environmental factors. Among dietary factors, high dextrose, low protein, methionine restriction, short-chain fatty acids (butyric acid and lipoic acid), and all- trans -retinoic acid were repeatedly shown to induce FGF21 expression and circulating levels. These effects are usually more pronounced in liver or isolated hepatocytes than in adipose tissue or isolated fat cells. Although peroxisome proliferator-activated receptor α (PPARα) is a key mediator of hepatic FGF21 expression and function, including the regulation of gluconeogenesis, ketogenesis, torpor, and growth inhibition, there is increasing evidence of PPARα-independent transactivation of the FGF21 gene by dietary molecules. FGF21 expression is believed to follow the circadian rhythm and be placed under the control of first order clock-controlled transcription factors, retinoic acid receptor-related orphan receptors (RORs) and nuclear receptors subfamily 1 group D (REV-ERBs), with FGF21 rhythm being anti-phase to REV-ERBs. Key metabolic hormones such as glucagon, insulin, and thyroid hormone have presumed or clearly demonstrated roles in regulating FGF21 transcription and secretion. The control of the FGF21 gene by glucagon and insulin appears more complex than first anticipated. Some discrepancies are noted and will need continued studies. The complexity in assessing the significance of FGF21 gene expression resides in the difficulty to ascertain (i) when transcription results in local or systemic increase of FGF21 protein; (ii) if FGF21 is among the first or second order genes upregulated by physiological, metabolic, and environmental stimuli, or merely an epiphenomenon; and (iii) whether FGF21 may have some adverse effects alongside beneficial outcomes." @default.
- W2417291010 created "2016-06-24" @default.
- W2417291010 creator A5029287868 @default.
- W2417291010 creator A5069150621 @default.
- W2417291010 date "2016-06-10" @default.
- W2417291010 modified "2023-10-11" @default.
- W2417291010 title "The regulation of <i>FGF21</i> gene expression by metabolic factors and nutrients" @default.
- W2417291010 cites W1515671273 @default.
- W2417291010 cites W1653996640 @default.
- W2417291010 cites W1757847430 @default.
- W2417291010 cites W1843104323 @default.
- W2417291010 cites W1863321457 @default.
- W2417291010 cites W1964799714 @default.
- W2417291010 cites W1968091833 @default.
- W2417291010 cites W1971732805 @default.
- W2417291010 cites W1972717747 @default.
- W2417291010 cites W1973692821 @default.
- W2417291010 cites W1975530669 @default.
- W2417291010 cites W1978555135 @default.
- W2417291010 cites W1978881179 @default.
- W2417291010 cites W1981894899 @default.
- W2417291010 cites W1982780910 @default.
- W2417291010 cites W1983397453 @default.
- W2417291010 cites W1988048122 @default.
- W2417291010 cites W1989584881 @default.
- W2417291010 cites W1990034097 @default.
- W2417291010 cites W1991713706 @default.
- W2417291010 cites W1999449586 @default.
- W2417291010 cites W2000368348 @default.
- W2417291010 cites W2000665430 @default.
- W2417291010 cites W2001449527 @default.
- W2417291010 cites W2003892421 @default.
- W2417291010 cites W2004645532 @default.
- W2417291010 cites W2005063766 @default.
- W2417291010 cites W2006024610 @default.
- W2417291010 cites W2006838809 @default.
- W2417291010 cites W2007078899 @default.
- W2417291010 cites W2010965956 @default.
- W2417291010 cites W2011072921 @default.
- W2417291010 cites W2011486862 @default.
- W2417291010 cites W2012853495 @default.
- W2417291010 cites W2014789141 @default.
- W2417291010 cites W2020408566 @default.
- W2417291010 cites W2021325073 @default.
- W2417291010 cites W2021743307 @default.
- W2417291010 cites W2022799160 @default.
- W2417291010 cites W2025139842 @default.
- W2417291010 cites W2026360229 @default.
- W2417291010 cites W2027273404 @default.
- W2417291010 cites W2027744584 @default.
- W2417291010 cites W2028284381 @default.
- W2417291010 cites W2029477556 @default.
- W2417291010 cites W2032787352 @default.
- W2417291010 cites W2037001212 @default.
- W2417291010 cites W2039155288 @default.
- W2417291010 cites W2042334427 @default.
- W2417291010 cites W2043914167 @default.
- W2417291010 cites W2047691125 @default.
- W2417291010 cites W2047726905 @default.
- W2417291010 cites W2048722931 @default.
- W2417291010 cites W2053972428 @default.
- W2417291010 cites W2055583675 @default.
- W2417291010 cites W2056045775 @default.
- W2417291010 cites W2060734703 @default.
- W2417291010 cites W2062522221 @default.
- W2417291010 cites W2062842771 @default.
- W2417291010 cites W2067743977 @default.
- W2417291010 cites W2069090380 @default.
- W2417291010 cites W2071549991 @default.
- W2417291010 cites W2073808722 @default.
- W2417291010 cites W2074443204 @default.
- W2417291010 cites W2075349430 @default.
- W2417291010 cites W2075731394 @default.
- W2417291010 cites W2076210772 @default.
- W2417291010 cites W2077327925 @default.
- W2417291010 cites W2079132151 @default.
- W2417291010 cites W2082972253 @default.
- W2417291010 cites W2090060547 @default.
- W2417291010 cites W2090556647 @default.
- W2417291010 cites W2094372926 @default.
- W2417291010 cites W2095864675 @default.
- W2417291010 cites W2096021452 @default.
- W2417291010 cites W2099579483 @default.
- W2417291010 cites W2103783819 @default.
- W2417291010 cites W2108364290 @default.
- W2417291010 cites W2111866285 @default.
- W2417291010 cites W2114373278 @default.
- W2417291010 cites W2115841218 @default.
- W2417291010 cites W2117059480 @default.
- W2417291010 cites W2119331212 @default.
- W2417291010 cites W2119351413 @default.
- W2417291010 cites W2120942865 @default.
- W2417291010 cites W2121049950 @default.
- W2417291010 cites W2122234101 @default.
- W2417291010 cites W2123250471 @default.
- W2417291010 cites W2126312769 @default.
- W2417291010 cites W2127322768 @default.
- W2417291010 cites W2128009708 @default.
- W2417291010 cites W2131044927 @default.
- W2417291010 cites W2131192628 @default.