Matches in SemOpenAlex for { <https://semopenalex.org/work/W2417301306> ?p ?o ?g. }
Showing items 1 to 61 of
61
with 100 items per page.
- W2417301306 endingPage "A30" @default.
- W2417301306 startingPage "A29.4" @default.
- W2417301306 abstract "<h3>Background/introduction</h3> Diagnosis of primary syphilis is confirmed by serological tests suggestive of the stage of the disease. In most cases specific (IgM/IgG) and non-specific (RPR) antibodies develop in response to primary treponemal infection. Lack of development of such antibodies is known to occur amongst HIV positive patients but is unusual among HIV negative patients with no significant comorbidities. <h3>Aim(s)/objectives</h3> To present a cluster of four cases of primary syphilis from our clinic with unexpected serological results. <h3>Methods</h3> We describe four unusual cases of HIV-negative MSM, all of whom presented with penile lesions (three chancres and an atypical lesion). These cases were identified by clinicians between July 2014 and January 2015. Clinical and laboratory records were retrospectively interrogated. Clinical photographs will be used to illustrate these cases. <h3>Results</h3> In all cases, patients with no history of previous syphilis returned positive results on one or more specific treponemal serological tests with persistently negative RPR. Three cases had recent negative syphilis screening at our clinic. Darkfield microscopy also failed to demonstrate T. pallidum in those with chancres. In all cases, treatment of presumed syphilis led to the resolution of the lesions. <h3>Discussion/conclusion</h3> These cases demonstrate the ongoing difficulties with treponemal diagnostic test interpretation. There are reports in the literature that men over 35 may be more likely to return a false negative RPR result, but overall prevalence of false negative RPR in primary syphilis is uncertain. Over-reliance on serology may result in under diagnosis of syphilis even in HIV-negative MSM." @default.
- W2417301306 created "2016-06-24" @default.
- W2417301306 creator A5062682148 @default.
- W2417301306 creator A5077936265 @default.
- W2417301306 date "2015-05-18" @default.
- W2417301306 modified "2023-09-26" @default.
- W2417301306 title "P44 Rpr-negative primary syphilis in men who have sex with men: a case series" @default.
- W2417301306 doi "https://doi.org/10.1136/sextrans-2015-052126.88" @default.
- W2417301306 hasPublicationYear "2015" @default.
- W2417301306 type Work @default.
- W2417301306 sameAs 2417301306 @default.
- W2417301306 citedByCount "0" @default.
- W2417301306 crossrefType "journal-article" @default.
- W2417301306 hasAuthorship W2417301306A5062682148 @default.
- W2417301306 hasAuthorship W2417301306A5077936265 @default.
- W2417301306 hasBestOaLocation W24173013061 @default.
- W2417301306 hasConcept C159654299 @default.
- W2417301306 hasConcept C16005928 @default.
- W2417301306 hasConcept C187212893 @default.
- W2417301306 hasConcept C203014093 @default.
- W2417301306 hasConcept C2776939746 @default.
- W2417301306 hasConcept C2776983459 @default.
- W2417301306 hasConcept C2780187896 @default.
- W2417301306 hasConcept C2908804808 @default.
- W2417301306 hasConcept C2910147798 @default.
- W2417301306 hasConcept C3013748606 @default.
- W2417301306 hasConcept C45189115 @default.
- W2417301306 hasConcept C71924100 @default.
- W2417301306 hasConceptScore W2417301306C159654299 @default.
- W2417301306 hasConceptScore W2417301306C16005928 @default.
- W2417301306 hasConceptScore W2417301306C187212893 @default.
- W2417301306 hasConceptScore W2417301306C203014093 @default.
- W2417301306 hasConceptScore W2417301306C2776939746 @default.
- W2417301306 hasConceptScore W2417301306C2776983459 @default.
- W2417301306 hasConceptScore W2417301306C2780187896 @default.
- W2417301306 hasConceptScore W2417301306C2908804808 @default.
- W2417301306 hasConceptScore W2417301306C2910147798 @default.
- W2417301306 hasConceptScore W2417301306C3013748606 @default.
- W2417301306 hasConceptScore W2417301306C45189115 @default.
- W2417301306 hasConceptScore W2417301306C71924100 @default.
- W2417301306 hasIssue "Suppl 1" @default.
- W2417301306 hasLocation W24173013061 @default.
- W2417301306 hasOpenAccess W2417301306 @default.
- W2417301306 hasPrimaryLocation W24173013061 @default.
- W2417301306 hasRelatedWork W2417301306 @default.
- W2417301306 hasRelatedWork W2756089982 @default.
- W2417301306 hasRelatedWork W3014834998 @default.
- W2417301306 hasRelatedWork W3023035317 @default.
- W2417301306 hasRelatedWork W3090554666 @default.
- W2417301306 hasRelatedWork W3119559590 @default.
- W2417301306 hasRelatedWork W3139691094 @default.
- W2417301306 hasRelatedWork W3178130307 @default.
- W2417301306 hasRelatedWork W4313477274 @default.
- W2417301306 hasRelatedWork W4377939159 @default.
- W2417301306 hasVolume "91" @default.
- W2417301306 isParatext "false" @default.
- W2417301306 isRetracted "false" @default.
- W2417301306 magId "2417301306" @default.
- W2417301306 workType "article" @default.