FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2417365713> ?p ?o ?g. }

• W2417365713 endingPage "556" @default.
• W2417365713 startingPage "545" @default.
• W2417365713 abstract "1. Microsomal preparations from rat liver, kidney and intestine were tested for UDP-glucuronyltransferase activity by using oestrone, oestradiol-17 beta, oestriol, testosterone, cortisol, cortisone, corticosterone, aldosterone, tetrahydrocortisol and tetrahydrocortisone as substrates. The microsomal preparation from the liver glucuronidated oestrone, oestradiol-17 beta and testosterone. 2. The specific activity of the enzyme was significantly higher in livers from female rats than in those from male rats. 3. Testosterone was actively glucuronidated by both sexes. Cortisol, cortisone, corticosterone, aldosterone, tetrahydrocortisol and tetrahydrocortisone were not glucuronidated by any of the three tissues. 4. The non-ionic detergent Lubrol WX activates liver microsomal UDP-glucuronyltransferase 2-3-fold with oestrone and testosterone as substrates. 5. Oestrone glucuronyltransferase was inhibited by oestradiol-17 beta, predominantly competitively and by testosterone non-competitively. Bilirubin was a non-competitive inhibitor of oestrone glucuronidation. p-Nitrophenol had no effect. 6. Oestrone glucuronyltransferase could not be stimulated by either acute or prolonged treatment of animals with phenobarbital, whereas a single dose of 3-methylcholanthrene led to a moderate stimulation. 7. Ovariectomy leads to a 56% decrease in oestrone glucuronyltransferase activity; administration of oestradiol-17 beta induces the enzyme to normal activity after 12 days, and after 15 days the activity is twice the control value. Actinomycin D and cycloheximide block the oestradiol-17 beta-induced increase in enzyme activity. 8. Castration has no effect on the activity of testosterone glucuronyltransferase, nor does administration of testosterone influence enzyme activity. The results provide strong evidence for the existence of multiple steroid glucuronyltransferases in the liver of the rat." @default.
• W2417365713 created "2016-06-24" @default.
• W2417365713 creator A5006001873 @default.
• W2417365713 creator A5026922386 @default.
• W2417365713 creator A5078057600 @default.
• W2417365713 creator A5080929179 @default.
• W2417365713 date "1977-03-15" @default.
• W2417365713 modified "2023-09-24" @default.
• W2417365713 title "Steroid glucuronyltransferases of rat liver. Properties of oestrone and testosterone glucuronyltransferases and the effect of ovariectomy, castration and administration of steroids on the enzymes" @default.
• W2417365713 cites W1540794543 @default.
• W2417365713 cites W1775749144 @default.
• W2417365713 cites W1775964807 @default.
• W2417365713 cites W1969031193 @default.
• W2417365713 cites W1971342293 @default.
• W2417365713 cites W1986180357 @default.
• W2417365713 cites W1997545177 @default.
• W2417365713 cites W2020779522 @default.
• W2417365713 cites W2036323751 @default.
• W2417365713 cites W2047536234 @default.
• W2417365713 cites W2051802102 @default.
• W2417365713 cites W2057380077 @default.
• W2417365713 cites W2064845513 @default.
• W2417365713 cites W2080345024 @default.
• W2417365713 cites W2088681467 @default.
• W2417365713 cites W2125792532 @default.
• W2417365713 cites W2134453931 @default.
• W2417365713 cites W2232332843 @default.
• W2417365713 cites W2327290560 @default.
• W2417365713 cites W2338851752 @default.
• W2417365713 cites W2365035905 @default.
• W2417365713 cites W2994309418 @default.
• W2417365713 cites W66925781 @default.
• W2417365713 doi "https://doi.org/10.1042/bj1620545" @default.
• W2417365713 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1164637" @default.
• W2417365713 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/869904" @default.
• W2417365713 hasPublicationYear "1977" @default.
• W2417365713 type Work @default.
• W2417365713 sameAs 2417365713 @default.
• W2417365713 citedByCount "49" @default.
• W2417365713 countsByYear W24173657132013 @default.
• W2417365713 countsByYear W24173657132017 @default.
• W2417365713 crossrefType "journal-article" @default.
• W2417365713 hasAuthorship W2417365713A5006001873 @default.
• W2417365713 hasAuthorship W2417365713A5026922386 @default.
• W2417365713 hasAuthorship W2417365713A5078057600 @default.
• W2417365713 hasAuthorship W2417365713A5080929179 @default.
• W2417365713 hasBestOaLocation W24173657132 @default.
• W2417365713 hasConcept C126322002 @default.
• W2417365713 hasConcept C134018914 @default.
• W2417365713 hasConcept C181199279 @default.
• W2417365713 hasConcept C185592680 @default.
• W2417365713 hasConcept C2777911890 @default.
• W2417365713 hasConcept C2778525890 @default.
• W2417365713 hasConcept C2778656385 @default.
• W2417365713 hasConcept C2779256933 @default.
• W2417365713 hasConcept C2779279991 @default.
• W2417365713 hasConcept C2779907587 @default.
• W2417365713 hasConcept C2780352252 @default.
• W2417365713 hasConcept C2780484280 @default.
• W2417365713 hasConcept C2781115071 @default.
• W2417365713 hasConcept C55493867 @default.
• W2417365713 hasConcept C71315377 @default.
• W2417365713 hasConcept C71924100 @default.
• W2417365713 hasConcept C86803240 @default.
• W2417365713 hasConcept C87644729 @default.
• W2417365713 hasConceptScore W2417365713C126322002 @default.
• W2417365713 hasConceptScore W2417365713C134018914 @default.
• W2417365713 hasConceptScore W2417365713C181199279 @default.
• W2417365713 hasConceptScore W2417365713C185592680 @default.
• W2417365713 hasConceptScore W2417365713C2777911890 @default.
• W2417365713 hasConceptScore W2417365713C2778525890 @default.
• W2417365713 hasConceptScore W2417365713C2778656385 @default.
• W2417365713 hasConceptScore W2417365713C2779256933 @default.
• W2417365713 hasConceptScore W2417365713C2779279991 @default.
• W2417365713 hasConceptScore W2417365713C2779907587 @default.
• W2417365713 hasConceptScore W2417365713C2780352252 @default.
• W2417365713 hasConceptScore W2417365713C2780484280 @default.
• W2417365713 hasConceptScore W2417365713C2781115071 @default.
• W2417365713 hasConceptScore W2417365713C55493867 @default.
• W2417365713 hasConceptScore W2417365713C71315377 @default.
• W2417365713 hasConceptScore W2417365713C71924100 @default.
• W2417365713 hasConceptScore W2417365713C86803240 @default.
• W2417365713 hasConceptScore W2417365713C87644729 @default.
• W2417365713 hasIssue "3" @default.
• W2417365713 hasLocation W24173657131 @default.
• W2417365713 hasLocation W24173657132 @default.
• W2417365713 hasLocation W24173657133 @default.
• W2417365713 hasLocation W24173657134 @default.
• W2417365713 hasOpenAccess W2417365713 @default.
• W2417365713 hasPrimaryLocation W24173657131 @default.
• W2417365713 hasRelatedWork W1974087230 @default.
• W2417365713 hasRelatedWork W1992438146 @default.
• W2417365713 hasRelatedWork W2010487533 @default.
• W2417365713 hasRelatedWork W2023266651 @default.
• W2417365713 hasRelatedWork W2030400955 @default.
• W2417365713 hasRelatedWork W2047828047 @default.
• W2417365713 hasRelatedWork W2052265245 @default.
• W2417365713 hasRelatedWork W2101146068 @default.

• next