FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2417370069> ?p ?o ?g. }

• W2417370069 abstract "Background Preventing organ damage is a major challenge in management of Systemic Lupus Erythematosus (SLE). Few data are available on factors related to development of damage in early stages of the disease. Objectives To evaluate the early damage accrual and factors determining development and progression of damage in a prospectively followed cohort of SLE patients. Methods The Early Lupus Project comprises 8 Italian centers recruiting, from the 1st January 2012, an inception cohort of consecutive patients diagnosed with SLE. Patients were enrolled within 12 months of recognition of four or more 1997 ACR classification criteria for SLE. At study entry and then every 6 months a large panel of data was recorded. Here, we report on the development and progression of damage assessed by the SLICC/ACR Damage Index (SDI) at 6-month and 12-month of disease. Using univariate analysis, we assessed the contribution of covariates collected at baseline (demographic, serological, clinical by BILAG2004 domains, disease activity by ECLAM index and health related quality of life by visual analogic scale) in the development of damage (SDI from 0 to ≥1) and increase in pre-existing damage within 12 months from diagnosis. Stepwise regression models were fitted with covariates with p Results A total of 161 patients were enrolled in the Early Lupus Project inception cohort up to December 2014; 108 patients (93% Caucasians, 17 males) were eligible for this study having at least 12 months of disease. Mean age at recognition of 4 ACR criteria was 36.3±14.1 years, mean disease duration at recruitment was 2.8±4.3 months (median =1 month; interquartile range 0-3.8). At 6 months of disease, 22 (20.3%) patients had an SDI score of 1 or more (20 patients scored SDI=1; 4 patients scored SDI=2; 3 patients scored SDI≥3). At 12 months of disease, 27 (25.0%) patients had an SDI score of 1 or more and only one patient had increase in pre-existing damage. Age (p=0.01), dyslipidemia (p Conclusions Development of organ damage begins early in patients with SLE as effect of modifiable and non-modifiable risk factors. Addressing these since the very early stages of the disease may improve short-term outcome. Disclosure of Interest None declared" @default.
• W2417370069 created "2016-06-24" @default.
• W2417370069 creator A5006082336 @default.
• W2417370069 creator A5018764793 @default.
• W2417370069 creator A5022954669 @default.
• W2417370069 creator A5023504237 @default.
• W2417370069 creator A5029683989 @default.
• W2417370069 creator A5042259427 @default.
• W2417370069 creator A5049244075 @default.
• W2417370069 creator A5050351597 @default.
• W2417370069 creator A5065129415 @default.
• W2417370069 creator A5082465903 @default.
• W2417370069 creator A5086701427 @default.
• W2417370069 creator A5088995264 @default.
• W2417370069 date "2015-06-01" @default.
• W2417370069 modified "2023-10-02" @default.
• W2417370069 title "FRI0410 Factors Associated with Early Damage Accrual in Patients with Systemic Lupus Erythematosus: 12-Month Preliminary Results from the Inception Cohort of the Multicenter Early Lupus Project" @default.
• W2417370069 doi "https://doi.org/10.1136/annrheumdis-2015-eular.5872" @default.
• W2417370069 hasPublicationYear "2015" @default.
• W2417370069 type Work @default.
• W2417370069 sameAs 2417370069 @default.
• W2417370069 citedByCount "0" @default.
• W2417370069 crossrefType "journal-article" @default.
• W2417370069 hasAuthorship W2417370069A5006082336 @default.
• W2417370069 hasAuthorship W2417370069A5018764793 @default.
• W2417370069 hasAuthorship W2417370069A5022954669 @default.
• W2417370069 hasAuthorship W2417370069A5023504237 @default.
• W2417370069 hasAuthorship W2417370069A5029683989 @default.
• W2417370069 hasAuthorship W2417370069A5042259427 @default.
• W2417370069 hasAuthorship W2417370069A5049244075 @default.
• W2417370069 hasAuthorship W2417370069A5050351597 @default.
• W2417370069 hasAuthorship W2417370069A5065129415 @default.
• W2417370069 hasAuthorship W2417370069A5082465903 @default.
• W2417370069 hasAuthorship W2417370069A5086701427 @default.
• W2417370069 hasAuthorship W2417370069A5088995264 @default.
• W2417370069 hasConcept C126322002 @default.
• W2417370069 hasConcept C144301174 @default.
• W2417370069 hasConcept C201903717 @default.
• W2417370069 hasConcept C2776912625 @default.
• W2417370069 hasConcept C2779134260 @default.
• W2417370069 hasConcept C38180746 @default.
• W2417370069 hasConcept C71924100 @default.
• W2417370069 hasConcept C72563966 @default.
• W2417370069 hasConceptScore W2417370069C126322002 @default.
• W2417370069 hasConceptScore W2417370069C144301174 @default.
• W2417370069 hasConceptScore W2417370069C201903717 @default.
• W2417370069 hasConceptScore W2417370069C2776912625 @default.
• W2417370069 hasConceptScore W2417370069C2779134260 @default.
• W2417370069 hasConceptScore W2417370069C38180746 @default.
• W2417370069 hasConceptScore W2417370069C71924100 @default.
• W2417370069 hasConceptScore W2417370069C72563966 @default.
• W2417370069 hasLocation W24173700691 @default.
• W2417370069 hasOpenAccess W2417370069 @default.
• W2417370069 hasPrimaryLocation W24173700691 @default.
• W2417370069 hasRelatedWork W1572534709 @default.
• W2417370069 hasRelatedWork W2053367430 @default.
• W2417370069 hasRelatedWork W2066550586 @default.
• W2417370069 hasRelatedWork W2077541411 @default.
• W2417370069 hasRelatedWork W2091679727 @default.
• W2417370069 hasRelatedWork W2158263012 @default.
• W2417370069 hasRelatedWork W2171096642 @default.
• W2417370069 hasRelatedWork W2410282912 @default.
• W2417370069 hasRelatedWork W2610360197 @default.
• W2417370069 hasRelatedWork W2736033975 @default.
• W2417370069 hasRelatedWork W2745074989 @default.
• W2417370069 hasRelatedWork W2808503865 @default.
• W2417370069 hasRelatedWork W2899267246 @default.
• W2417370069 hasRelatedWork W2901300444 @default.
• W2417370069 hasRelatedWork W2908241962 @default.
• W2417370069 hasRelatedWork W2909770510 @default.
• W2417370069 hasRelatedWork W2938268041 @default.
• W2417370069 hasRelatedWork W2981105658 @default.
• W2417370069 hasRelatedWork W3084889460 @default.
• W2417370069 hasRelatedWork W3202751186 @default.
• W2417370069 isParatext "false" @default.
• W2417370069 isRetracted "false" @default.
• W2417370069 magId "2417370069" @default.
• W2417370069 workType "article" @default.