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• W2417377577 abstract "No AccessJournal of Urology1 Jan 1990Proteins of the Rat Prostate. III Effect of Testosterone on Protein Synthesis by the Ventral Prostate of Castrated Rats Julia A. Sensibar, Brad Alger, Anne Tseng, Lori Berg, and Chung Lee Julia A. SensibarJulia A. Sensibar More articles by this author , Brad AlgerBrad Alger More articles by this author , Anne TsengAnne Tseng More articles by this author , Lori BergLori Berg More articles by this author , and Chung LeeChung Lee More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)39902-0AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Protein synthetic activities in the ventral prostate were assessed by two-dimensional electrophoresis in either four-day or seven-day castrated rats at different intervals following subcutaneous implantation of testosterone-filled silastic tubings for a period of up to four days. Prostatic tissues were cut into one to two mm.3 pieces and incubated in tissue culture medium containing S35-methionine (100µCi/ml) at 37C under 95% oxygen and 5% carbon dioxide for four hours. The incubated tissues were subjected to two-dimensional electrophoresis and radiofluorography. Analysis of protein spots detected in the fluorograms by computer-assisted densitometry revealed temporal changes in the synthesis of individual proteins by the ventral prostate of castrated rats following androgen treatment. Changes in two groups of proteins were evaluated: castration-induced proteins and androgen-dependent proteins. The level of synthesis of three castration-induced proteins (spots G, H, and I) declined rapidly upon testosterone treatment and reached a non-detectable level for spots G and H and a low level of synthesis for spot I by three days following androgen treatment. Synthesis of androgen-dependent proteins (spots D, E, and F) was activated by testosterone treatment. However, the time interval required to activate the synthesis of these proteins is different. Synthesis of protein spot D (prostatic binding protein) was detected as soon as half hour after the treatment. Synthesis of spots E and F, on the other hand, was not activated until 24 and 48 hours after the treatment, respectively. These changes in patterns of protein synthesis represent the characteristics of cellular responses to testosterone stimulation by the regressed prostate. © 1990 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited ByDE MARZO A, NELSON W, MEEKER A and COFFEY D (2018) STEM CELL FEATURES OF BENIGN AND MALIGNANT PROSTATE EPITHELIAL CELLSJournal of Urology, VOL. 160, NO. 6 Part 2, (2381-2392), Online publication date: 1-Dec-1998.Borchers H, Meyers F, Gumerlock P, Stewart S and Devere White R (2018) NM23 Gene Expression in Human Prostatic Carcinomas and Benign Prostatic Hyperplasias: Altered Expression in Combined Androgen Blockaded CarcinomasJournal of Urology, VOL. 155, NO. 6, (2080-2084), Online publication date: 1-Jun-1996. Volume 143Issue 1January 1990Page: 161-166 Advertisement Copyright & Permissions© 1990 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Julia A. Sensibar More articles by this author Brad Alger More articles by this author Anne Tseng More articles by this author Lori Berg More articles by this author Chung Lee More articles by this author Expand All Advertisement Loading ..." @default.
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• W2417377577 title "Proteins of the Rat Prostate. III Effect of Testosterone on Protein Synthesis by the Ventral Prostate of Castrated Rats" @default.
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