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- W2417398479 abstract "This chapter presents a working hypothesis for prostaglandin action, which will enable the determination of the possible significance of these substances in their own branches of medicine and biology. In doing so, the chapter lays the basis for elucidation of the possible biological role of the prostaglandins. It mainly deals with the action of prostaglandins in those systems where the adenyl cyclase system has been implicated. A great deal of evidence has now accumulated indicating that many of the pharmacological effects of the prostaglandins are manifest in those systems where cyclic AMP is believed to mediate the response of the hormone. Initially, three factors led to the realization that prostaglandins might interact with the cyclic AMP-forming system in a regulatory capacity. In the first observation, it was found PGE1-inhibited epinephrine-stimulated lipolysis. Lipolysis is believed to be mediated via cyclic AMP, and an increase in the intracellular concentration of the nucleotide is thought to be the rate-limiting step in the activation of a triglyceride lipase. In a study described in the chapter, it was demonstrated that in fat pads, the antagonism by PGE1 of lipolysis was associated with the inhibition of cyclic AMP accumulation; this inhibitory effect of PGE1 has since been demonstrated in isolated fat cells." @default.
- W2417398479 created "2016-06-24" @default.
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- W2417398479 date "1970-01-01" @default.
- W2417398479 modified "2023-10-16" @default.
- W2417398479 title "Biological Significance of the Prostaglandins" @default.
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- W2417398479 doi "https://doi.org/10.1016/b978-0-12-571126-5.50008-x" @default.
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