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- W2417413071 abstract "Objective To investigate the effects of estrogen on the activity and subunits expression of cytochrome c oxidase (COX) in mitochondria from genioglossus of chronic intermittent hypoxia (CIH)rat.Methods Forty-eight male Spragne-Dawley (SD) rats were randomly divided into three groups:the normal control group (NC),the chronic intermittent hypoxia group (CIH) and estrogen plus hypoxia group(E + CIH).Rats in the latter two groups were used to build CIH models(8 h/d,5 w).In the mean time,rats in NC group and CIH group were injected with sterile olive oil (0.2 ml each time, twice a week),and rats in E + CIH group were injected with estrogen (0.2 mg/kg,twice a week),respectively. At the end of the treatment,the genioglossus of the rat was removed and the mitechondrla were isolated by centrifugation program.COX activity was measured with a spectrophotometer.The protein content of COX subunit I and IV was detected by Western blotting analysis,and mRNA expression levels of COX Ⅰ and COX Ⅳ were determined by real-time polymerase chain action.Results COX activity in CIH group [(0.143±0.029) μkat/mg] was lower significantly than that in NC group [(0.273±0.058)μkat/mg, P＜0.01];In E + CIH group [(0.203±0.073) μkat/mg],COX activity was higher than that in CIH group(P＜0.05),but still lower than that in NC group (P＜0.05).Compared with NC group (47.325±7.502),decreased COX I expression was observed in CIH group (10.789±8.144,P＜0.01) and E +CIH group (25.593 +11.108,P＜0.01).While in the mean time, the protein content of COX I in E +CIH group was higher than that in CIH group (P＜0.05).There was no significant difference in protein content of COXlV among the three groups (P＞0.05).COXI and COXIV mRNA levels had no significant change among the three groups (P＞0.05).Conclusions CIH exposure could decrease mitochondrial COX protein expression and activity in the genioglossns of the rat,while estrogen administration might be beneficial to the recovery of those.Key words: Estrogens; Cyteehrome c; Anoxia; Gene expression; Genioglossus" @default.
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- W2417413071 date "2008-10-01" @default.
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- W2417413071 title "Effects of estrogen on activity and subunits expression of cytochrome C oxidase in mitochondria from genioglossus of rats subjected to chronic intermittent hypoxia" @default.
- W2417413071 doi "https://doi.org/10.3321/j.issn:1002-0098.2008.10.008" @default.
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