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• W2417425923 abstract "We have analyzed the Danish national drug director y (Medicine.dk) and found that it provides the information from industrial drug trial s instead of the more objective and reliable information on the drugs provided by meta-analyses made by researchers independent of the pharmaceutical industry, like the Cochrane collabor ation. The consequence of this is a strong bias, as a large fraction of the drugs are presented more po sitive and less harmful than they actually are. Whole classes of drugs that in independent meta-ana lyses have been found to be of little clinical value, or even harmful, are still listed in the nat ional drug directories as beneficial drugs, i.e. an ti- cancer chemotherapy, the anti-depressive drugs, and the anti-psychotic drugs. To solve this serious problem of misguidance, we have identified the core principles for rational listening of data regardin g positive and negative effects of the pharmaceutical drugs. An outline of a standard list of positive a nd negative drug effects is suggested. Information on each drug should be provided with due regard to dose, indication of use, all clinically relevant ou tcomes, method of drug study used for documentation, including placebo type, and the quality of the study. We recommend the use of Number Needed to Treat (NNT) and Number Needed to Harm (NNH) for each single situation. When more objective and reliable data exist, they should be preferred rather than more doubtful data from studies of lower quality. We warn physicians and pa tients that the existing drug directory is strongly biased and not a reliable source of information." @default.
• W2417425923 created "2016-06-24" @default.
• W2417425923 creator A5068793378 @default.
• W2417425923 creator A5080073763 @default.
• W2417425923 date "2010-04-01" @default.
• W2417425923 modified "2023-09-24" @default.
• W2417425923 title "A review of the Danish National Drug Directory: Who provides the data for the register?" @default.
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