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- W2417449849 abstract "A novel biodegradable PLGA/TiO(2) organic-inorganic hybrid nano-material was prepared by the reaction between activated carboxyl-terminated PLGA, which was synthesized by PLGA and succinic anhydride with TEA as catalyzer, and amino-terminated TiO(2) nano-particles which were modified by amino propyltriethoxysilane (KH550). The structure and morphology of the materials were characterized by Fourier transform infrared spectroscopy (FTIR), (1)H nuclear magnetic resonance ((1)H-NMR), thermogravimetic analysis (TGA), environmental scanning electron microscopy (ESEM) and transmission electron microscopy (TEM) methods. The results showed that the PLGA was grafted successfully on the surface of nano scale TiO2 particles with 14% average grafting; PLGA/TiO(2) hybrid nano-material dispersed uniformly in BSA aqueous solution without obvious aggregation and showed a better adsorptivity (81. 3%) to model drug BSA as compared with that(43. 3%) of pure TiO(2) nanoparticles. Different kinds of the nanopaticles containing proteins BSA (TiO(2)-BSA and PLGA/TiO(2)-BSA) were loaded into polymer microspheres with PLGA as carrier by the solid-in-oil-in-water emulsion method. The drug loading content, entrapment efficiency and drug release in vitro of different drug containing microspheres were tested. The results indicated that the microspheres of PTB/P showed smooth morphologies, high entrapment efficiency 96% and drug loading content 14.6% and decreased burst effect of drug, compared with TB/P microspheres." @default.
- W2417449849 created "2016-06-24" @default.
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- W2417449849 date "2011-01-01" @default.
- W2417449849 modified "2023-09-25" @default.
- W2417449849 title "PREPARATION AND CHARACTERIZATION OF PLGA/TiO(2) NANO DRUG DELIBERY CARRIERS" @default.
- W2417449849 hasPublicationYear "2011" @default.
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